Genetics of Parkinson's disease: an introspection of its journey towards precision medicine
S Bandres-Ciga, M Diez-Fairen, JJ Kim… - Neurobiology of …, 2020 - Elsevier
ABSTRACT A substantial proportion of risk for Parkinson's disease (PD) is driven by
genetics. Progress in understanding the genetic basis of PD has been significant. So far …
genetics. Progress in understanding the genetic basis of PD has been significant. So far …
[HTML][HTML] Monogenic Parkinson's disease: genotype, phenotype, pathophysiology, and genetic testing
Genes | Free Full-Text | Monogenic Parkinson’s Disease: Genotype, Phenotype,
Pathophysiology, and Genetic Testing Next Article in Journal enChIP-Seq Analyzer: A …
Pathophysiology, and Genetic Testing Next Article in Journal enChIP-Seq Analyzer: A …
Parkinson's disease: proteinopathy or lipidopathy?
Lipids play a more significant role in Parkinson's disease and its related brain disorders than
is currently recognized, supporting a “lipid cascade”. The 14 kDa protein α-synuclein (αS) is …
is currently recognized, supporting a “lipid cascade”. The 14 kDa protein α-synuclein (αS) is …
Genetics of Parkinson's disease
Less than a quarter century after the discovery of SNCA as the first attributable gene in
Parkinson's disease (PD), our knowledge of the genetic architecture underlying this disease …
Parkinson's disease (PD), our knowledge of the genetic architecture underlying this disease …
Proteostasis in Parkinson's disease: Recent development and possible implication in diagnosis and therapeutics
A Kulkarni, K Preeti, KP Tryphena, S Srivastava… - Ageing Research …, 2023 - Elsevier
The protein dyshomeostasis is identified as the hallmark of many age-related
neurodegenerative disorders including Parkinson's disease (PD). The diseased brain shows …
neurodegenerative disorders including Parkinson's disease (PD). The diseased brain shows …
Genotype-phenotype correlations in monogenic Parkinson disease: a review on clinical and molecular findings
Parkinson disease (PD) is a complex neurodegenerative disorder, usually with multifactorial
etiology. It is characterized by prominent movement disorders and non-motor symptoms …
etiology. It is characterized by prominent movement disorders and non-motor symptoms …
LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson's disease and …
MM Grochowska, A Carreras Mascaro… - Acta …, 2021 - Springer
Loss-of-function variants in the low-density lipoprotein receptor-related protein 10 (LRP10)
gene have been associated with autosomal-dominant Parkinson's disease (PD), PD …
gene have been associated with autosomal-dominant Parkinson's disease (PD), PD …
Precision medicine in Parkinson's disease: from genetic risk signals to personalized therapy
G Straccia, F Colucci, R Eleopra, R Cilia - Brain Sciences, 2022 - mdpi.com
Understanding the pathophysiology and genetic background of Parkinson's disease (PD)
increases the likelihood of developing effective disease-modifying therapeutic strategies. In …
increases the likelihood of developing effective disease-modifying therapeutic strategies. In …
LRP10, PGK1 and RPLP0: best reference genes in periprostatic adipose tissue under obesity and prostate cancer conditions
JM Pérez-Gómez, F Porcel-Pastrana… - International Journal of …, 2023 - mdpi.com
Obesity (OB) is a metabolic disorder characterized by adipose tissue dysfunction that has
emerged as a health problem of epidemic proportions in recent decades. OB is associated …
emerged as a health problem of epidemic proportions in recent decades. OB is associated …