Micronuclei as biomarkers of DNA damage, aneuploidy, inducers of chromosomal hypermutation and as sources of pro-inflammatory DNA in humans
M Fenech, S Knasmueller, C Bolognesi… - … Research/Reviews in …, 2020 - Elsevier
Micronuclei (MNi) are among the most widely studied biomarkers of DNA damage and
chromosomal instability in humans. They originate from chromosome fragments or intact …
chromosomal instability in humans. They originate from chromosome fragments or intact …
The HUman MicroNucleus project on eXfoLiated buccal cells (HUMNXL): The role of life-style, host factors, occupational exposures, health status, and assay protocol
The human buccal micronucleus cytome assay (BMCyt) is one of the most widely used
techniques to measure genetic damage in human population studies. Reducing protocol …
techniques to measure genetic damage in human population studies. Reducing protocol …
Cytokinesis-block micronucleus cytome assay
M Fenech - Nature protocols, 2007 - nature.com
The cytokinesis-block micronucleus cytome assay is a comprehensive system for measuring
DNA damage, cytostasis and cytotoxicity. DNA damage events are scored specifically in …
DNA damage, cytostasis and cytotoxicity. DNA damage events are scored specifically in …
HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures
M Fenech, WP Chang, M Kirsch-Volders… - … /Genetic Toxicology and …, 2003 - Elsevier
Criteria for scoring micronuclei and nucleoplasmic bridges in binucleated cells in the
cytokinesis-block micronucleus assay for isolated human lymphocyte cultures are described …
cytokinesis-block micronucleus assay for isolated human lymphocyte cultures are described …
The effect of age, gender, diet and lifestyle on DNA damage measured using micronucleus frequency in human peripheral blood lymphocytes
Micronucleus (MN) frequency in cytokinesis-blocked peripheral blood lymphocytes (PBL)
has become one of the best-established biomarkers for studying DNA damage occurring in …
has become one of the best-established biomarkers for studying DNA damage occurring in …
Chromosomal changes: induction, detection methods and applicability in human biomonitoring
R Mateuca, N Lombaert, PV Aka, I Decordier… - Biochimie, 2006 - Elsevier
The objective of this state of the art paper is to review the mechanisms of induction, the fate,
the methodology, the sensitivity/specificity and predictivity of two major cytogenetic …
the methodology, the sensitivity/specificity and predictivity of two major cytogenetic …
The micronucleus assay as a biological dosimeter of in vivo ionising radiation exposure
Biological dosimetry, based on the analysis of micronuclei (MN) in the cytokinesis-block
micronucleus (CBMN) assay can be used as an alternative method for scoring dicentric …
micronucleus (CBMN) assay can be used as an alternative method for scoring dicentric …
The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance
M Kirsch-Volders, G Plas, A Elhajouji… - Archives of …, 2011 - Springer
Micronuclei (MN) are small, extranuclear bodies that arise in dividing cells from acentric
chromosome/chromatid fragments or whole chromosomes/chromatids lagging behind in …
chromosome/chromatid fragments or whole chromosomes/chromatids lagging behind in …
[HTML][HTML] Micronuclei and genome chaos: changing the system inheritance
CJ Ye, Z Sharpe, S Alemara, S Mackenzie, G Liu… - Genes, 2019 - mdpi.com
Micronuclei research has regained its popularity due to the realization that genome chaos, a
rapid and massive genome re-organization under stress, represents a major common …
rapid and massive genome re-organization under stress, represents a major common …
[HTML][HTML] The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and …
The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular
methods for assessing DNA damage in human population. One of the open issues …
methods for assessing DNA damage in human population. One of the open issues …