Life exists in three dimensions, but until the turn of the century most electron microscopy
methods provided only 2D image data. Recently, electron microscopy techniques capable of …

Connections between neurons can be mapped by acquiring and analysing electron
microscopic brain images. In recent years, this approach has been applied to chunks of …

Brains contain networks of interconnected neurons and so knowing the network architecture
is essential for understanding brain function. We therefore mapped the synaptic-resolution …

Establishing how neural function emerges from network properties is a fundamental problem
in neuroscience. Here, to better understand the relationship between the structure and the …

Dense reconstruction of synaptic connectivity requires high-resolution electron microscopy
images of entire brains and tools to efficiently trace neuronal wires across the volume. To …

The brain is a complex system comprising a myriad of interacting neurons, posing significant
challenges in understanding its structure, function, and dynamics. Network science has …

Efforts are ongoing to map synaptic wiring diagrams, or connectomes, to understand the
neural basis of brain function. However, chemical synapses represent only one type of …

Since the Cambrian, animals diversified from a few body forms or bauplans, into many
extinct and all extant species. A characteristic neural architecture serves each bauplan. How …

Animal bodies are composed of cell types with unique expression programs that implement
their distinct locations, shapes, structures, and functions. Based on these properties, cell …

For most model organisms in neuroscience, research into visual processing in the brain is
difficult because of a lack of high-resolution maps that capture complex neuronal circuitry …