During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

Extracorporeal membrane oxygenation (ECMO) causes both thrombosis and bleeding.
Major society guidelines recommend continuous, systemic anticoagulation to prevent …

Pulmonary embolism is a common and potentially fatal cardiovascular disorder that must be
promptly diagnosed and treated. The diagnosis, risk assessment, and management of …

The development of extracorporeal life support technology has added a new dimension to
the care of critically ill patients who fail conventional treatment options. Extracorporeal …

Since the initial description in 2019, the novel coronavirus SARS-Cov-2 infection (COVID-
19) pandemic has swept the globe. The most severe form of the disease presents with fever …

As the third most common vascular disease, venous thromboembolism is associated with
significant mortality and morbidity. Pathogenesis underlying venous thrombosis is still not …

Thrombo-inflammation describes the complex interplay between blood coagulation and
inflammation that plays a critical role in cardiovascular diseases. The third Maastricht …

Clinicians have been more and more often encountering patients with venous
thromboembolism (VTE), including pulmonary embolism and deep vein thrombosis, leading …

Coagulation factor XII (FXII), a S1A serine protease, was discovered more than fifty years
ago. However, its in vivo functions and its three-dimensional structure started to be disclosed …

Exposure of blood to a foreign surface in the form of a diagnostic or therapeutic biomaterial
device or implanted cells or tissue elicits an immediate, evolutionarily conserved …