[HTML][HTML] Revisited metabolic control and reprogramming cancers by means of the warburg effect in tumor cells
Aerobic glycolysis is an emerging hallmark of many human cancers, as cancer cells are
defined as a “metabolically abnormal system”. Carbohydrates are metabolically …
defined as a “metabolically abnormal system”. Carbohydrates are metabolically …
Deregulated transcription factors in cancer cell metabolisms and reprogramming
Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer
malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to …
malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to …
[HTML][HTML] Hypoxia: syndicating triple negative breast cancer against various therapeutic regimens
N Srivastava, SS Usmani, R Subbarayan… - Frontiers in …, 2023 - frontiersin.org
Triple-negative breast cancer (TNBC) is one of the deadliest subtypes of breast cancer (BC)
for its high aggressiveness, heterogeneity, and hypoxic nature. Based on biological and …
for its high aggressiveness, heterogeneity, and hypoxic nature. Based on biological and …
[HTML][HTML] Regulation of the HIF switch in human endothelial and cancer cells
J Slawski, M Jaśkiewicz, A Barton, S Kozioł… - European Journal of …, 2024 - Elsevier
Hypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome
for cells to survive hypoxic insults and oxidative stress. They are important during embryonic …
for cells to survive hypoxic insults and oxidative stress. They are important during embryonic …
[HTML][HTML] CRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1α
X Fu, Q Zhang, Z Wang, Y Xu, Q Dong - Cell Death & Disease, 2024 - nature.com
Ovarian cancer is the most lethal malignancy among gynecologic cancers, and primary and
secondary chemotherapy resistance is one of the important reasons for poor prognosis of …
secondary chemotherapy resistance is one of the important reasons for poor prognosis of …
Cellular signaling in the hypoxic cancer microenvironment: Implications for drug resistance and therapeutic targeting
The rewiring of cellular metabolism is a defining characteristic of cancer, as tumor cells
adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability …
adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability …
[HTML][HTML] Acute vs. chronic vs. intermittent hypoxia in breast Cancer: a review on its application in in vitro research
Q Liu, VAC Palmgren, EHJ Danen… - Molecular biology …, 2022 - Springer
Hypoxia has been linked to elevated instances of therapeutic resistance in breast cancer.
The exposure of proliferating cancer cells to hypoxia has been shown to induce an …
The exposure of proliferating cancer cells to hypoxia has been shown to induce an …
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment
A Moinuddin, SM Poznanski, AL Portillo… - Immunological …, 2024 - Wiley Online Library
Natural Killer (NK) cells are a top contender in the development of adoptive cell therapies for
cancer due to their diverse antitumor functions and ability to restrict their activation against …
cancer due to their diverse antitumor functions and ability to restrict their activation against …
[HTML][HTML] Macrophage-derived extracellular vesicles: A promising tool for personalized cancer therapy
The incidence of cancer is increasing dramatically, affecting all ages of the population and
reaching an ever higher worldwide mortality rate. The lack of therapies' efficacy is due to …
reaching an ever higher worldwide mortality rate. The lack of therapies' efficacy is due to …
Biological function, regulatory mechanism, and clinical application of mannose in cancer
H Jin, X Liu, H Liu - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Studies examining the regulatory roles and clinical applications of monosaccharides other
than glucose in cancer have been neglected. Mannose, a common type of monosaccharide …
than glucose in cancer have been neglected. Mannose, a common type of monosaccharide …