Aerobic glycolysis is an emerging hallmark of many human cancers, as cancer cells are
defined as a “metabolically abnormal system”. Carbohydrates are metabolically …

Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer
malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to …

Triple-negative breast cancer (TNBC) is one of the deadliest subtypes of breast cancer (BC)
for its high aggressiveness, heterogeneity, and hypoxic nature. Based on biological and …

Hypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome
for cells to survive hypoxic insults and oxidative stress. They are important during embryonic …

Ovarian cancer is the most lethal malignancy among gynecologic cancers, and primary and
secondary chemotherapy resistance is one of the important reasons for poor prognosis of …

The rewiring of cellular metabolism is a defining characteristic of cancer, as tumor cells
adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability …

Hypoxia has been linked to elevated instances of therapeutic resistance in breast cancer.
The exposure of proliferating cancer cells to hypoxia has been shown to induce an …

Natural Killer (NK) cells are a top contender in the development of adoptive cell therapies for
cancer due to their diverse antitumor functions and ability to restrict their activation against …

The incidence of cancer is increasing dramatically, affecting all ages of the population and
reaching an ever higher worldwide mortality rate. The lack of therapies' efficacy is due to …

Studies examining the regulatory roles and clinical applications of monosaccharides other
than glucose in cancer have been neglected. Mannose, a common type of monosaccharide …