We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

Amyotrophic lateral sclerosis (ALS) is the commonest form of motor neuron disease and is a
fatal, degenerative, multisystem disorder affecting upper and/or lower motor neurons in the …

Amyotrophic lateral sclerosis and Parkinson's disease are neurodegenerative diseases of
the motor system which are now recognized also to affect non-motor pathways. Non-motor …

Widespread appreciation that neuroplasticity is an essential feature of the neural system
controlling breathing has emerged only in recent years. In this chapter, we focus on …

Neuroplasticity is an important property of the neural system controlling breathing. However,
our appreciation for its importance is still relatively new, and we have much to learn …

A hallmark feature of the neural system controlling breathing is its ability to exhibit plasticity.
Less appreciated is the ability to exhibit metaplasticity, a change in the capacity to express …

Inspiratory accessory respiratory muscles (ARMs) enhance ventilation when demands are
high, such as during exercise and/or pathological conditions. Despite progressive …

Mutations in superoxide dismutase 1 (SOD1) cause 15–20% of familial amyotrophic lateral
sclerosis (fALS) cases. The resulting amino acid substitutions destabilize SOD1's protein …

Neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease are incurable diseases with progressive loss of neural function and …

Rationale: Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease
resulting in respiratory failure and death. Use of noninvasive ventilation (NIV) improves …