Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …

INTRODUCTION Mammalian embryos frequently develop abnormally, resulting in
miscarriages and genetic disorders such as Down syndrome. The major cause for aberrant …

The centrosome acts as the major microtubule-organizing center (MTOC) for cytoskeleton
maintenance in interphase and mitotic spindle assembly in vertebrate cells. It duplicates …

Kinetochore fibres (K‐fibres) of the spindle apparatus move chromosomes during mitosis.
These fibres are discrete bundles of parallel microtubules (MTs) that are crosslinked by inter …

The selective degradation of target proteins with small molecules is a novel approach to the
treatment of various diseases, including cancer. We have developed a protein knockdown …

Transforming acidic coiled coil 3 (TACC3) is a non-motor microtubule-associated protein
(MAP) that is important for mitotic spindle stability and organisation. The exact mechanism …

Acomplex of transforming acidic coiled-coil protein 3 (TACC3), colonic and hepatic tumor
overexpressed gene (ch-TOG), and clathrin has been implicated in mitotic spindle assembly …

Fibroblast growth factor receptors (FGFR) are critical for cell proliferation and differentiation.
Mutation and/or translocation of FGFRs lead to aberrant signaling that often results in …

Centrosome amplification (CA) is a hallmark of cancer that is strongly associated with highly
aggressive disease and worse clinical outcome. Clustering extra centrosomes is a major …