Chagas disease: from discovery to a worldwide health problem

KCF Lidani, FA Andrade, L Bavia… - Frontiers in public …, 2019 - frontiersin.org
Carlos Chagas discovered American trypanosomiasis, also named Chagas disease (CD) in
his honor, just over a century ago. He described the clinical aspects of the disease …

Chagas disease in the United States: a public health approach

C Bern, LA Messenger, JD Whitman… - Clinical microbiology …, 2019 - Am Soc Microbiol
Trypanosoma cruzi is the etiological agent of Chagas disease, usually transmitted by
triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal …

Randomized trial of benznidazole for chronic Chagas' cardiomyopathy

CA Morillo, JA Marin-Neto, A Avezum… - … England Journal of …, 2015 - Mass Medical Soc
Background The role of trypanocidal therapy in patients with established Chagas'
cardiomyopathy is unproven. Methods We conducted a prospective, multicenter …

Chagas' disease

C Bern - New England Journal of Medicine, 2015 - Mass Medical Soc
Chagas’ Disease | New England Journal of Medicine Skip to main content The New England
Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical …

Chagas disease

JA Pérez-Molina, I Molina - The Lancet, 2018 - thelancet.com
Chagas disease is an anthropozoonosis from the American continent that has spread from
its original boundaries through migration. It is caused by the protozoan Trypanosoma cruzi …

II Consenso Brasileiro em doença de Chagas, 2015

JCP Dias, AN Ramos Jr, ED Gontijo… - … e Serviços de …, 2016 - SciELO Public Health
RESUMO A doença de Chagas é uma condição crônica negligenciada com elevada carga
de morbimortalidade e impacto dos pontos de vista psicológico, social e econômico …

Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled …

F Torrico, J Gascon, L Ortiz, C Alonso-Vega… - The Lancet Infectious …, 2018 - thelancet.com
Background Chagas disease is a major neglected vector-borne disease. In this study, we
investigated the safety and efficacy of three oral E1224 (a water-soluble ravuconazole …

[HTML][HTML] 2 nd Brazilian Consensus on Chagas Disease, 2015

JCP Dias, AN Ramos Jr, ED Gontijo… - Revista da Sociedade …, 2016 - SciELO Brasil
Chagas disease is a neglected chronic condition with a high burden of morbidity and
mortality. It has considerable psychological, social, and economic impacts. The disease …

Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial

CA Morillo, H Waskin, S Sosa-Estani… - Journal of the American …, 2017 - jacc.org
Background: Benznidazole is recommended for treatment of Chagas infection. Effects of
combination therapy with benznidazole and posaconazole have not been tested in …

Chagas disease drug discovery: toward a new era

E Chatelain - Journal of biomolecular screening, 2015 - journals.sagepub.com
American trypanosomiasis, or Chagas disease, is the result of infection by the Trypanosoma
cruzi parasite. Endemic in Latin America where it is the major cause of death from …