Small-molecule inhibitors targeting FOXM1: current challenges and future perspectives in cancer treatments

S Raghuwanshi, AL Gartel - Biochimica et Biophysica Acta (BBA)-Reviews …, 2023 - Elsevier
Forkhead box (FOX) protein M1 (FOXM1) is a critical proliferation-associated transcription
factor (TF) that is aberrantly overexpressed in the majority of human cancers and has also …

Targeting prolyl isomerase Pin1 as a promising strategy to overcome resistance to cancer therapies

W Wu, X Xue, Y Chen, N Zheng, J Wang - Pharmacological Research, 2022 - Elsevier
The development of tumor therapeutic resistance is one of the important reasons for the
failure of antitumor therapy. Starting with multiple targets and multiple signaling pathways is …

Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling …

D Hu, RY Meng, TV Nguyen… - Molecular …, 2022 - spandidos-publications.com
Colorectal cancer (CRC) is one of the deadliest malignant tumors worldwide and its
prevalence is increasing in South Korea. The efficacy of combined treatment with natural …

Dual-drug controllable co-assembly nanosystem for targeted and synergistic treatment of hepatocellular carcinoma

JQ Le, XH Song, LW Tong, YQ Lin, KK Feng… - Journal of Colloid and …, 2024 - Elsevier
The effectiveness of chemotherapeutic agents for hepatocellular carcinoma (HCC) is
unsatisfactory because of tumor heterogeneity, multidrug resistance, and poor target …

Ursolic acid ameliorated neuronal damage by restoring microglia-activated MMP/TIMP imbalance in vitro

L Qiu, Y Wang, Y Wang, F Liu, S Deng… - Drug Design …, 2023 - Taylor & Francis
Purpose The oxygen and glucose deprivation-reoxygenation (OGDR) model is widely used
to evaluate ischemic stroke and cerebral ischemia-reperfusion (I/R) injury in vitro …

Synergistic anti-tumor effect of dual drug co-assembled nanoparticles based on ursolic acid and sorafenib

LW Tong, JQ Le, XH Song, CL Li, SJ Yu, YQ Lin… - Colloids and Surfaces B …, 2024 - Elsevier
Both ursolic acid (UA) and sorafenib (Sora) have been generally utilized in cancer treatment,
and the combination of the two has also shown a good anti-tumor effect. However, single …

miRNAs as short non-coding RNAs in regulating doxorubicin resistance

S Mirzaei, MDA Paskeh, FA Moghadam… - Journal of Cell …, 2023 - Springer
The treatment of cancer patients has been prohibited by chemoresistance. Doxorubicin
(DOX) is an anti-tumor compound disrupting proliferation and triggering cell cycle arrest via …

Unveiling the potential of ursolic acid modified hyaluronate nanoparticles for combination drug therapy in triple negative breast cancer

R Sharma, V Yadav, S Jha, S Dighe, S Jain - Carbohydrate Polymers, 2024 - Elsevier
Triple negative breast cancer (TNBC) represents the most aggressive and heterogenous
disease, and combination therapy holds promising potential. Here, an enzyme-responsive …

Role of ursolic acid in preventing gastrointestinal cancer: recent trends and future perspectives

A Chauhan, VM Pathak, M Yadav… - Frontiers in …, 2024 - frontiersin.org
Gastrointestinal malignancies are one of the major worldwide health concerns. In the
present review, we have assessed the plausible therapeutic implication of Ursolic Acid (UA) …

Hyaluronic acid functionalized liposomes for co-delivery of paclitaxel and ursolic acid for enhanced efficacy against triple negative breast cancer

R Sharma, V Yadav, O Katari, S Jain - Journal of Drug Delivery Science …, 2025 - Elsevier
Triple negative breast cancer (TNBC) stands out as an aggressive and lethal subtype of
breast cancer. Despite being a mainstay in treatment, the efficacy of paclitaxel (PTX) …