Small-molecule inhibitors targeting FOXM1: current challenges and future perspectives in cancer treatments
S Raghuwanshi, AL Gartel - Biochimica et Biophysica Acta (BBA)-Reviews …, 2023 - Elsevier
Forkhead box (FOX) protein M1 (FOXM1) is a critical proliferation-associated transcription
factor (TF) that is aberrantly overexpressed in the majority of human cancers and has also …
factor (TF) that is aberrantly overexpressed in the majority of human cancers and has also …
Targeting prolyl isomerase Pin1 as a promising strategy to overcome resistance to cancer therapies
W Wu, X Xue, Y Chen, N Zheng, J Wang - Pharmacological Research, 2022 - Elsevier
The development of tumor therapeutic resistance is one of the important reasons for the
failure of antitumor therapy. Starting with multiple targets and multiple signaling pathways is …
failure of antitumor therapy. Starting with multiple targets and multiple signaling pathways is …
Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling …
D Hu, RY Meng, TV Nguyen… - Molecular …, 2022 - spandidos-publications.com
Colorectal cancer (CRC) is one of the deadliest malignant tumors worldwide and its
prevalence is increasing in South Korea. The efficacy of combined treatment with natural …
prevalence is increasing in South Korea. The efficacy of combined treatment with natural …
Dual-drug controllable co-assembly nanosystem for targeted and synergistic treatment of hepatocellular carcinoma
JQ Le, XH Song, LW Tong, YQ Lin, KK Feng… - Journal of Colloid and …, 2024 - Elsevier
The effectiveness of chemotherapeutic agents for hepatocellular carcinoma (HCC) is
unsatisfactory because of tumor heterogeneity, multidrug resistance, and poor target …
unsatisfactory because of tumor heterogeneity, multidrug resistance, and poor target …
Ursolic acid ameliorated neuronal damage by restoring microglia-activated MMP/TIMP imbalance in vitro
L Qiu, Y Wang, Y Wang, F Liu, S Deng… - Drug Design …, 2023 - Taylor & Francis
Purpose The oxygen and glucose deprivation-reoxygenation (OGDR) model is widely used
to evaluate ischemic stroke and cerebral ischemia-reperfusion (I/R) injury in vitro …
to evaluate ischemic stroke and cerebral ischemia-reperfusion (I/R) injury in vitro …
Synergistic anti-tumor effect of dual drug co-assembled nanoparticles based on ursolic acid and sorafenib
LW Tong, JQ Le, XH Song, CL Li, SJ Yu, YQ Lin… - Colloids and Surfaces B …, 2024 - Elsevier
Both ursolic acid (UA) and sorafenib (Sora) have been generally utilized in cancer treatment,
and the combination of the two has also shown a good anti-tumor effect. However, single …
and the combination of the two has also shown a good anti-tumor effect. However, single …
miRNAs as short non-coding RNAs in regulating doxorubicin resistance
S Mirzaei, MDA Paskeh, FA Moghadam… - Journal of Cell …, 2023 - Springer
The treatment of cancer patients has been prohibited by chemoresistance. Doxorubicin
(DOX) is an anti-tumor compound disrupting proliferation and triggering cell cycle arrest via …
(DOX) is an anti-tumor compound disrupting proliferation and triggering cell cycle arrest via …
Unveiling the potential of ursolic acid modified hyaluronate nanoparticles for combination drug therapy in triple negative breast cancer
Triple negative breast cancer (TNBC) represents the most aggressive and heterogenous
disease, and combination therapy holds promising potential. Here, an enzyme-responsive …
disease, and combination therapy holds promising potential. Here, an enzyme-responsive …
Role of ursolic acid in preventing gastrointestinal cancer: recent trends and future perspectives
Gastrointestinal malignancies are one of the major worldwide health concerns. In the
present review, we have assessed the plausible therapeutic implication of Ursolic Acid (UA) …
present review, we have assessed the plausible therapeutic implication of Ursolic Acid (UA) …
Hyaluronic acid functionalized liposomes for co-delivery of paclitaxel and ursolic acid for enhanced efficacy against triple negative breast cancer
Triple negative breast cancer (TNBC) stands out as an aggressive and lethal subtype of
breast cancer. Despite being a mainstay in treatment, the efficacy of paclitaxel (PTX) …
breast cancer. Despite being a mainstay in treatment, the efficacy of paclitaxel (PTX) …