Membrane lipid composition: effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues

D Casares, PV Escribá, CA Rosselló - International journal of molecular …, 2019 - mdpi.com
Biological membranes are key elements for the maintenance of cell architecture and
physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the …

Membrane homeostasis beyond fluidity: control of membrane compressibility

MF Renne, R Ernst - Trends in Biochemical Sciences, 2023 - cell.com
Biomembranes are complex materials composed of lipids and proteins that
compartmentalize biochemistry. They are actively remodeled in response to physical and …

Regulation of lipid saturation without sensing membrane fluidity

S Ballweg, E Sezgin, M Doktorova, R Covino… - Nature …, 2020 - nature.com
Cells maintain membrane fluidity by regulating lipid saturation, but the molecular
mechanisms of this homeoviscous adaptation remain poorly understood. We have …

Host lipids in positive-strand RNA virus genome replication

Z Zhang, G He, NA Filipowicz, G Randall… - Frontiers in …, 2019 - frontiersin.org
Membrane association is a hallmark of the genome replication of positive-strand RNA
viruses [(+) RNA viruses]. All well-studied (+) RNA viruses remodel host membranes and …

Engineering microbial membranes to increase stress tolerance of industrial strains

Y Qi, H Liu, X Chen, L Liu - Metabolic Engineering, 2019 - Elsevier
The microbial membrane serves as a biological barrier that separates the interior of cells
from the external environment, thus playing an important role in tolerance to stress …

Inhibiting stearoyl-CoA desaturase ameliorates α-synuclein cytotoxicity

BM Vincent, DF Tardiff, JS Piotrowski, R Aron… - Cell reports, 2018 - cell.com
The lack of disease-modifying treatments for neurodegenerative disease stems in part from
our rudimentary understanding of disease mechanisms and the paucity of targets for …

Role of cell membrane homeostasis in the pathogenicity of pathogenic filamentous fungi

Y Peng, B Chen - Virulence, 2024 - Taylor & Francis
The cell membrane forms a fundamental part of all living cells and participates in a variety of
physiological processes, such as material exchange, stress response, cell recognition …

The role of phospholipid molecular species in determining the physical properties of yeast membranes

MF Renne, AIPM de Kroon - FEBS letters, 2018 - Wiley Online Library
In most eukaryotes, including Saccharomyces cerevisiae, glycerophospholipids are the
main membrane lipid constituents. Besides serving as general membrane 'building blocks' …

Endoplasmic reticulum membrane homeostasis and the unfolded protein response

R Ernst, MF Renne, A Jain… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
The endoplasmic reticulum (ER) is the key organelle for membrane biogenesis. Most lipids
are synthesized in the ER, and most membrane proteins are first inserted into the ER …

Alleviation of postharvest chilling injury of carambola fruit by γ-aminobutyric acid: Physiological, biochemical, and structural characterization

F Ngaffo Mekontso, W Duan, EHM Cisse, T Chen… - Frontiers in …, 2021 - frontiersin.org
Chilling injury is a physiological disorder affecting the quality of carambola fruit. In the
present study, the effect of exogenous γ-aminobutyric acid (GABA) on CI development in …