[HTML][HTML] Breast cancer cell line classification and its relevance with breast tumor subtyping
X Dai, H Cheng, Z Bai, J Li - Journal of Cancer, 2017 - ncbi.nlm.nih.gov
Breast cancer cell lines have been widely used for breast cancer modelling which
encompasses a panel of diseases with distinct phenotypical associations. Though cell lines …
encompasses a panel of diseases with distinct phenotypical associations. Though cell lines …
[HTML][HTML] Paclitaxel's mechanistic and clinical effects on breast cancer
Paclitaxel (PTX), the most widely used anticancer drug, is applied for the treatment of
various types of malignant diseases. Mechanisms of PTX action represent several ways in …
various types of malignant diseases. Mechanisms of PTX action represent several ways in …
[HTML][HTML] A comparative analysis of individual RAS mutations in cancer biology
C Muñoz-Maldonado, Y Zimmer, M Medová - Frontiers in oncology, 2019 - frontiersin.org
In human cells, three closely related RAS genes, termed HRAS, KRAS, and NRAS, encode
four highly homologous proteins. RAS proteins are small GTPases involved in a broad …
four highly homologous proteins. RAS proteins are small GTPases involved in a broad …
Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy
PM Comoglio, L Trusolino, C Boccaccio - Nature Reviews Cancer, 2018 - nature.com
The MET oncogene encodes an unconventional receptor tyrosine kinase with pleiotropic
functions: it initiates and sustains neoplastic transformation when genetically altered …
functions: it initiates and sustains neoplastic transformation when genetically altered …
[HTML][HTML] Prognostic and predictive value of PDL1 expression in breast cancer
Expression of programmed cell death receptor ligand 1 (PDL1) has been scarcely studied in
breast cancer. Recently PD1/PDL1-inhibitors have shown promising results in different …
breast cancer. Recently PD1/PDL1-inhibitors have shown promising results in different …
[HTML][HTML] Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
PB Gupta, CM Fillmore, G Jiang, SD Shapira, K Tao… - Cell, 2011 - cell.com
Cancer cells within individual tumors often exist in distinct phenotypic states that differ in
functional attributes. While cancer cell populations typically display distinctive equilibria in …
functional attributes. While cancer cell populations typically display distinctive equilibria in …
Chromatin-modifying enzymes as modulators of reprogramming
Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming
involves global epigenetic remodelling. Whereas several proteins are known to regulate …
involves global epigenetic remodelling. Whereas several proteins are known to regulate …
[HTML][HTML] Evaluation of MCF10A as a reliable model for normal human mammary epithelial cells
Breast cancer is the most common cancer in women and a leading cause of cancer-related
deaths for women worldwide. Various cell models have been developed to study breast …
deaths for women worldwide. Various cell models have been developed to study breast …
Triple-negative breast cancer: disease entity or title of convenience?
This Review outlines the understanding and management of triple-negative breast cancer
(TNBC). TNBC shares morphological and genetic abnormalities with basal-like breast …
(TNBC). TNBC shares morphological and genetic abnormalities with basal-like breast …
[HTML][HTML] Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer
KJ Chavez, SV Garimella, S Lipkowitz - Breast disease, 2010 - ncbi.nlm.nih.gov
Breast cancer is the most frequently diagnosed cancer in women and one of the leading
causes of cancer death for women. Worldwide, over 1.3 million cases of invasive breast …
causes of cancer death for women. Worldwide, over 1.3 million cases of invasive breast …