Alterations in glutamatergic neurotransmission are implicated in the pathophysiology of
depression, and the glutamatergic system represents a treatment target for depression. To …

Background Electrical stimulation of the auricular branch of the vagus nerve (ABVN) via
transcutaneous auricular vagus nerve stimulation (taVNS) may influence afferent vagal …

Half a century after the first formulation of the monoamine hypothesis, compelling evidence
implies that long-term changes in an array of brain areas and circuits mediating complex …

There is now a wealth of evidence that anterior insular and anterior cingulate cortices have a
close functional relationship, such that they may be considered together as input and output …

l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …

Whole-brain neuroimaging studies have demonstrated regional variations in function within
human cingulate cortex. At the same time, regional variations in cingulate anatomical …

Obsessive compulsive disorder is prevalent, disabling, incompletely understood, and often
resistant to current therapies. Established treatments consist of specialized cognitive …

Serotonin reuptake inhibitors (SRIs), the first-line pharmacological treatment for obsessive-
compulsive disorder (OCD), have two limitations: incomplete symptom relief and 2–3 months …

A growing body of evidence has suggested that the dysfunction of glutamatergic systems
plays a pivotal role in major depressive disorder (MDD). In clinical studies, an N-methyl-d …

Depression is the most frequent psychiatric comorbidity in people with epilepsy (PWE) with
lifetime prevalence rates ranging between 30 and 35%. Multifactorial variables play a …