Even though “procholinergic” drugs are almost the sole kind of treatments currently used as
cognitive enhancers in patients with Alzheimer's disease, the role of acetylcholine (ACh) in …

For over a century, clinicians have consistently described the paradoxical co-existence in
posttraumatic stress disorder (PTSD) of sensory intrusive hypermnesia and declarative …

Do learning and retrieval of a memory activate the same neurons? Does the number of
reactivated neurons correlate with memory strength? We developed a transgenic mouse that …

The multiple-memory-systems framework—that distinct types of memory are supported by
distinct brain systems—has guided learning and memory research for decades. However …

Posttraumatic stress disorder (PTSD) is characterized by a hypermnesia of the trauma and
by a memory impairment that decreases the ability to restrict fear to the appropriate context …

Functional imaging studies of cued fear conditioning in humans have mostly confirmed
findings in animals, but it is unclear whether the brain mechanisms that underlie contextual …

Hospitalized patients can develop cognitive function decline, the mechanisms of which
remain largely to be determined. Sleep disturbance often occurs in hospitalized patients …

Post-traumatic stress disorder (PTSD) is characterized by emotional hypermnesia on which
preclinical studies focus so far. While this hypermnesia relates to salient traumatic cues …

Cholinergic activation regulates cognitive function, particularly long‐term memory
consolidation. This Review presents an overview of the anatomical, neurochemical, and …

Cholinergic input to the neocortex, dorsal hippocampus (dHipp), and basolateral amygdala
(BLA) is critical for neural function and synaptic plasticity in these brain regions. Synaptic …