Signal transduction cascades regulating fungal development and virulence

KB Lengeler, RC Davidson, C D'souza… - Microbiology and …, 2000 - Am Soc Microbiol
Cellular differentiation, mating, and filamentous growth are regulated in many fungi by
environmental and nutritional signals. For example, in response to nitrogen limitation …

The unfolded protein response in nutrient sensing and differentiation

RJ Kaufman, D Scheuner, M Schröder… - … reviews Molecular cell …, 2002 - nature.com
Eukaryotic cells coordinate protein-folding reactions in the endoplasmic reticulum with gene
expression in the nucleus and messenger RNA translation in the cytoplasm. As the rate of …

Dissecting the regulatory circuitry of a eukaryotic genome

FCP Holstege, EG Jennings, JJ Wyrick, TI Lee… - Cell, 1998 - cell.com
Genome-wide expression analysis was used to identify genes whose expression depends
on the functions of key components of the transcription initiation machinery in yeast …

Large‐scale essential gene identification in Candida albicans and applications to antifungal drug discovery

T Roemer, B Jiang, J Davison, T Ketela… - Molecular …, 2003 - Wiley Online Library
Candida albicans is the primary fungal pathogen of humans. Despite the need for novel
drugs to combat fungal infections [Sobel, JD (2000) Clin Infectious Dis 30: 652], antifungal …

Dectin‐1 mediates macrophage recognition of Candida albicans yeast but not filaments

BN Gantner, RM Simmons, DM Underhill - The EMBO journal, 2005 - embopress.org
The ability of Candida albicans to rapidly and reversibly switch between yeast and
filamentous morphologies is crucial to pathogenicity, and it is thought that the filamentous …

Modular organization of cellular networks

AW Rives, T Galitski - … of the national Academy of sciences, 2003 - National Acad Sciences
We investigated the organization of interacting proteins and protein complexes into networks
of modules. A network-clustering method was developed to identify modules. This method of …

Cdc42: an essential Rho-type GTPase controlling eukaryotic cell polarity

DI Johnson - Microbiology and Molecular Biology Reviews, 1999 - Am Soc Microbiol
Cdc42p is an essential GTPase that belongs to the Rho/Rac subfamily of Ras-like GTPases.
These proteins act as molecular switches by responding to exogenous and/or endogenous …

A MAP kinase of the vascular wilt fungus Fusarium oxysporum is essential for root penetration and pathogenesis

A Di Pietro, FI García‐Maceira, E Méglecz… - Molecular …, 2001 - Wiley Online Library
The soil‐borne vascular wilt fungus Fusarium oxysporum infects a wide variety of plant
species by directly penetrating roots, invading the cortex and colonizing the vascular tissue …

Polarization of cell growth in yeast II. The role of the cortical actin cytoskeleton

D Pruyne, A Bretscher - Journal of cell science, 2000 - journals.biologists.com
The actin cytoskeleton provides the structural basis for cell polarity in Saccharomyces
cerevisiae as well as most other eukaryotes. In Part I of this two-part commentary, presented …

[HTML][HTML] NRG1, a repressor of filamentous growth in C. albicans, is down‐regulated during filament induction

BR Braun, D Kadosh, AD Johnson - The EMBO journal, 2001 - embopress.org
In response to a variety of external signals, the fungal pathogen Candida albicans
undergoes a transition between ellipsoidal single cells (blastospores) and filaments …