[HTML][HTML] Chitosan: a potential biopolymer in drug delivery and biomedical applications

N Desai, D Rana, S Salave, R Gupta, P Patel… - Pharmaceutics, 2023 - mdpi.com
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has
surfaced as a material of promise for drug delivery and biomedical applications. Different …

[HTML][HTML] Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics

DV Bhalani, B Nutan, A Kumar, AK Singh Chandel - Biomedicines, 2022 - mdpi.com
The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

Plant‐derived extracellular vesicles: Recent advancements and current challenges on their use for biomedical applications

MQ Lian, WH Chng, J Liang, HQ Yeo… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) represent a diverse class of lipid bilayer membrane vesicles
released by both animal and plant cells. These ubiquitous vesicles are involved in …

[HTML][HTML] Advances in drug delivery systems, challenges and future directions

TC Ezike, US Okpala, UL Onoja, CP Nwike, EC Ezeako… - Heliyon, 2023 - cell.com
Advances in molecular pharmacology and an improved understanding of the mechanism of
most diseases have created the need to specifically target the cells involved in the initiation …

[HTML][HTML] A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

C Kofink, N Trainor, B Mair, S Wöhrle, M Wurm… - Nature …, 2022 - nature.com
Targeted protein degradation offers an alternative modality to classical inhibition and holds
the promise of addressing previously undruggable targets to provide novel therapeutic …

RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract

SS Srinivasan, A Alshareef, AV Hwang, Z Kang… - Science robotics, 2022 - science.org
Oral drug delivery of proteins is limited by the degradative environment of the
gastrointestinal tract and poor absorption, requiring parenteral administration of these drugs …

Mucoadhesive carriers for oral drug delivery

R Kumar, T Islam, M Nurunnabi - Journal of Controlled Release, 2022 - Elsevier
Among the various dosage forms, oral medicine has extensive benefits including ease of
administration and patients' compliance, over injectable, suppositories, ocular and nasal …

Mechanisms of nanoparticle transport across intestinal tissue: an oral delivery perspective

SA Ejazi, R Louisthelmy, K Maisel - ACS nano, 2023 - ACS Publications
Oral drug administration has been a popular choice due to patient compliance and limited
clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) …

[HTML][HTML] Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation approaches

L Shipp, F Liu, L Kerai-Varsani, TC Okwuosa - Journal of Controlled …, 2022 - Elsevier
The potential of the mucoadhesive film technology is hard to ignore, owing to perceived
superior patient acceptability versus buccal tablets, and significant therapeutic opportunities …

[HTML][HTML] Advancements in antimicrobial nanoscale materials and self-assembling systems

JA Doolan, GT Williams, KLF Hilton… - Chemical Society …, 2022 - pubs.rsc.org
Antimicrobial resistance is directly responsible for more deaths per year than either
HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at …