White matter hyperintensities (WMH) are commonly seen in the brain of healthy elderly
subjects and patients with several neurological and vascular disorders. A truly reliable and …

Background: White matter hyperintensities of presumed vascular origin (WMH) are a
common finding in elderly people and a growing social malady in the aging western …

Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen
on neuroimaging include recent small subcortical infarcts, lacunes, white matter …

Introduction Small vessel disease (SVD) is a common contributor to dementia. Subtle blood-
brain barrier (BBB) leakage may be important in SVD-induced brain damage. Methods We …

White matter hyperintensities (WMH) of presumed vascular origin are a common finding in
brain magnetic resonance imaging of older individuals and contribute to cognitive and …

Objective: To determine the magnitude of potentially causal relationships among vascular
risk factors (VRFs), large-artery atheromatous disease (LAD), and cerebral white matter …

Objective To investigate cerebrovascular reactivity (CVR), blood flow, vascular and CSF
pulsatility, and their independent relationship with cerebral small vessel disease (SVD) …

White matter hyperintensities accumulate with age and occur in patients with stroke, but their
pathogenesis is poorly understood. We measured multiple magnetic resonance imaging …

There is evidence that subtle breakdown of the blood–brain barrier (BBB) is a
pathophysiological component of several diseases, including cerebral small vessel disease …

Objectives: Increased participation in leisure and physical activities may be cognitively
protective. Whether activity might protect the integrity of the brain's white matter, or reduce …