Acetaminophen hepatotoxicity: Paradigm for understanding mechanisms of drug-induced liver injury
H Jaeschke, A Ramachandran - Annual Review of Pathology …, 2024 - annualreviews.org
Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …
western countries, and, because of translational relevance of animal models, APAP is …
[HTML][HTML] Mitochondria in acetaminophen-induced liver injury and recovery: a concise review
A Ramachandran, H Jaeschke - Livers, 2023 - mdpi.com
Mitochondria are critical organelles responsible for the maintenance of cellular energy
homeostasis. Thus, their dysfunction can have severe consequences in cells responsible for …
homeostasis. Thus, their dysfunction can have severe consequences in cells responsible for …
Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging
JY Akakpo, H Olivos, B Shrestha, A Midey… - Toxicological …, 2024 - academic.oup.com
Acute kidney injury (AKI) is a common complication in acetaminophen (APAP) overdose
patients and can negatively impact prognosis. Unfortunately, N-acetylcysteine, which is the …
patients and can negatively impact prognosis. Unfortunately, N-acetylcysteine, which is the …
[HTML][HTML] Targeting cathepsin C ameliorates murine acetaminophen-induced liver injury
J Raith, M Bachmann, S Gonther, H Stülb… - Theranostics, 2024 - ncbi.nlm.nih.gov
Acetaminophen (APAP) overdosing is a major cause of acute liver failure worldwide and an
established model for drug-induced acute liver injury (ALI). While studying gene expression …
established model for drug-induced acute liver injury (ALI). While studying gene expression …
[HTML][HTML] The multifaceted role of macrophages during acute liver injury
GS Hassan, M Flores Molina, NH Shoukry - Frontiers in Immunology, 2023 - frontiersin.org
The liver is situated at the interface of the gut and circulation where it acts as a filter for blood-
borne and gut-derived microbes and biological molecules, promoting tolerance of non …
borne and gut-derived microbes and biological molecules, promoting tolerance of non …
[HTML][HTML] Interleukin-10 disrupts liver repair in acetaminophen-induced acute liver failure
K Roth, J Strickland, A Pant, R Freeborn… - Frontiers in …, 2023 - frontiersin.org
Introduction Systemic levels of the anti-inflammatory cytokine interleukin 10 (IL-10) are
highest in acetaminophen (APAP)-induced acute liver failure (ALF) patients with the poorest …
highest in acetaminophen (APAP)-induced acute liver failure (ALF) patients with the poorest …
Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight
DS Umbaugh, H Jaeschke - Expert Review of Clinical …, 2024 - Taylor & Francis
Introduction Acetaminophen (APAP) overdose is the leading cause of drug-induced liver
injury and can cause a rapid progression to acute liver failure (ALF). Therefore, the …
injury and can cause a rapid progression to acute liver failure (ALF). Therefore, the …
The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans
MR McGill - Drug Metabolism and Disposition, 2023 - ASPET
Our understanding of the fundamental molecular mechanisms of APAP hepatotoxicity began
in 1973-1974 when investigators at the US National Institutes of Health published seminal …
in 1973-1974 when investigators at the US National Institutes of Health published seminal …
[HTML][HTML] The p21+ perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying …
DS Umbaugh, NT Nguyen, SH Smith… - Toxicology, 2024 - Elsevier
Fifty percent of all acute liver failure (ALF) cases in the United States are due to
acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as …
acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as …
Myeloid‐Mas Signaling Modulates Pathogenic Crosstalk among MYC+CD63+ Endothelial Cells, MMP12+ Macrophages, and Monocytes in Acetaminophen …
S Chen, Z Lu, Y Zhao, L Xia, C Liu, S Zuo… - Advanced …, 2024 - Wiley Online Library
Acetaminophen overdose is a leading cause of acute liver failure (ALF). Despite the pivotal
role of the inflammatory microenvironment in the progression of advanced acetaminophen …
role of the inflammatory microenvironment in the progression of advanced acetaminophen …