Protein arginine methylation: from enigmatic functions to therapeutic targeting
Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …
Amino acid metabolism in health and disease
ZN Ling, YF Jiang, JN Ru, JH Lu, B Ding… - Signal Transduction and …, 2023 - nature.com
Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia
MB Pappalardi, K Keenan, M Cockerill, WA Kellner… - Nature cancer, 2021 - nature.com
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally
dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as …
dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as …
The regulation, functions and clinical relevance of arginine methylation
E Guccione, S Richard - Nature reviews Molecular cell biology, 2019 - nature.com
Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved
in the regulation of fundamental cellular processes, including transcription, RNA processing …
in the regulation of fundamental cellular processes, including transcription, RNA processing …
[HTML][HTML] Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
Although mutations in DNA are the best-studied source of neoantigens that determine
response to immune checkpoint blockade, alterations in RNA splicing within cancer cells …
response to immune checkpoint blockade, alterations in RNA splicing within cancer cells …
Protein arginine methyltransferases: promising targets for cancer therapy
JW Hwang, Y Cho, GU Bae, SN Kim… - Experimental & molecular …, 2021 - nature.com
Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …
9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy
Immune checkpoint therapy (ICT) provides substantial clinical benefits to cancer patients,
but a large proportion of cancers do not respond to ICT. To date, the genomic underpinnings …
but a large proportion of cancers do not respond to ICT. To date, the genomic underpinnings …
Cellular pathways influenced by protein arginine methylation: Implications for cancer
Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
[HTML][HTML] PRMT5 function and targeting in cancer
H Kim, AR Ze'ev - Cell stress, 2020 - ncbi.nlm.nih.gov
Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …
cancer development, progression and therapy-response. Here we discuss the function of …
PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity
Activation of the cGAS/STING innate immunity pathway is essential and effective for anti-
tumor immunotherapy. However, it remains largely elusive how tumor-intrinsic cGAS …
tumor immunotherapy. However, it remains largely elusive how tumor-intrinsic cGAS …