Direct interactions between proteins are essential for the regulation of their functions in
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …

Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …

3-3 proteins are highly conserved regulatory proteins that interact with hundreds of
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …

This chapter includes a historic overview of 14-3-3 proteins with an emphasis on the
differences between potentially cancer-relevant isoforms on the genomic, protein and …

14-3-3 proteins were the first signaling molecules to be identified as discrete phosphoserine/
threonine binding modules. This family of proteins, which includes seven isotypes in human …

Background Proteins are involved in many interactions with other proteins leading to
networks that regulate and control a wide variety of physiological processes. Some of these …

In the last 30 years, twin studies have indicated a strong genetic contribution to Autism
Spectrum Disorders (ASD). The heritability of ASD is estimated to be 50%, mostly captured …

The 14-3-3 proteins, a family of conserved regulatory molecules, participate in a wide range
of cellular processes through binding interactions with hundreds of structurally and …

Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells.
Following genotoxic stress, diverse molecular signals must be integrated to establish …

More than 200 phosphorylated 14-3-3-binding sites in the literature were analysed to define
14-3-3 specificities, identify relevant protein kinases, and give insights into how cellular 14-3 …