Highlights•New technology to profile the adaptive immune system with high-throughput
sequencing of adaptive immune receptors.•Ability to follow the dynamics of an adaptive …

Despite years of preclinical efforts and hundreds of clinical studies, therapeutic cancer
vaccines with the routine ability to limit or eliminate tumor growth in humans have been …

Allogeneic hematopoietic stem cell transplantation (HSCT) is one of curative treatment
options for patients with hematologic malignancies. Although GVHD mediated by the donor's …

The year 2020 marked the 30th anniversary of the Nobel Prize in Medicine awarded to E.
Donnall Thomas for the development of allogeneic hematopoietic stem cell transplantation …

Abstract The Human Leukocyte Antigen (HLA) system has a critical role in
immunorecognition, transplantation, and disease association. Early typing techniques …

Umbilical cord blood (UCB) is now widely used as an alternative hematopoietic stem cell
source for patients lacking closely matched related or unrelated adult donors. UCB …

Background T-cell-mediated rejection (TCMR) remains a major cause of kidney allograft
failure. The characterization of T-cell repertoire in different immunological disorders has …

Allogeneic stem cell transplantation (alloSCT) is used for treating patients with T-
prolymphocytic leukemia (T-PLL). However, direct evidence of GvL activity in T-PLL is …

With the introduction of the next generation sequencing (NGS) technologies, remarkable
new diagnostic applications have been established in daily routine. Implementation of NGS …

Application of next generation sequencing (NGS) has shed light on the molecular
heterogeneity of hematological malignancies. NGS panels targeting recurrent mutations …