Cyclical fate restriction: a new view of neural crest cell fate specification

RN Kelsh, K Camargo Sosa, S Farjami… - …, 2021 - journals.biologists.com
Neural crest cells are crucial in development, not least because of their remarkable
multipotency. Early findings stimulated two hypotheses for how fate specification and …

Zebrafish as a model system to study the mechanism of cutaneous wound healing and drug discovery: advantages and challenges

R Naomi, H Bahari, MD Yazid, H Embong, F Othman - Pharmaceuticals, 2021 - mdpi.com
In humans, cutaneous wounds may heal without scars during embryogenesis. However, in
the adult phase, the similar wound may undergo a few events such as homeostasis, blood …

The role of wnt/β-catenin signalling in neural crest development in zebrafish

G Sutton, RN Kelsh, S Scholpp - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
The neural crest (NC) is a multipotent cell population in vertebrate embryos with
extraordinary migratory capacity. The NC is crucial for vertebrate development and forms a …

Novel generic models for differentiating stem cells reveal oscillatory mechanisms

S Farjami, K Camargo Sosa… - Journal of The …, 2021 - royalsocietypublishing.org
Understanding cell fate selection remains a central challenge in developmental biology. We
present a class of simple yet biologically motivated mathematical models for cell …

Cell fate decisions in the neural crest, from pigment cell to neural development

JHP Dawes, RN Kelsh - International Journal of Molecular Sciences, 2021 - mdpi.com
The neural crest shows an astonishing multipotency, generating multiple neural derivatives,
but also pigment cells, skeletogenic and other cell types. The question of how this process is …

MITF deficiency and oncogenic GNAQ each promote proliferation programs in zebrafish melanocyte lineage cells

GB Phelps, A Amsterdam, HR Hagen… - Pigment Cell & …, 2022 - Wiley Online Library
Uveal melanoma (UM) is the most common primary malignancy of the adult eye but lacks
any FDA‐approved therapy for the deadly metastatic disease. Thus, there is a great need to …