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Potential drug–drug interactions mediated by the ATP-binding cassette (ABC) transporter
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …

The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22
(solute carrier 22) transporter family, has received a great deal of attention because of its …

Membrane transporters can be major determinants of the pharmacokinetic, safety and
efficacy profiles of drugs. This presents several key questions for drug development …

Diabetic kidney disease is the leading cause of ESRD, but few biomarkers of diabetic kidney
disease are available. This study used gas chromatography-mass spectrometry to quantify …

The human organic anion and cation transporters are classified within two SLC
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

The proximal tubule of the kidney plays a crucial role in the renal handling of drugs (eg,
diuretics), uremic toxins (eg, indoxyl sulfate), environmental toxins (eg, mercury, aristolochic …

In vitro data indicates that the kidney proximal tubule (PT) transporters of uremic toxins and
solutes (eg, indoxyl sulfate, p-cresol sulfate, kynurenine, creatinine, urate) include two “drug” …

The SLC22 transporter family consists of more than two dozen members, which are
expressed in the kidney, the liver, and other tissues. Evolutionary analysis indicates that …