The mononuclear phagocyte system (MPS) is defined as a cell lineage in which committed
marrow progenitors give rise to blood monocytes and tissue macrophages. Here, we discuss …

An immune response must be tightly controlled so that it will be commensurate with the level
of response needed to protect the organism without damaging normal tissue. The roles of …

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …

Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …

Simple Summary Laboratory animals are fundamental in biomedical science and monitoring
their health and metabolic processes is essential to ensure their welfare and the quality of …

This focus issue of Lab Animal coincides with a tipping point in biomedical research. For the
first time, the scale of the reproducibility and translatability crisis is widely understood …

Interest in space habitation has grown dramatically with planning underway for the first
human transit to Mars. Despite a robust history of domestic and international spaceflight …

To best promote animal wellbeing and the efficacy of biomedical models, scientific,
husbandry, and veterinary professionals must consider the mechanisms, influences, and …

The growth of advanced, custom microscopy has outpaced commercialization, with
biologists unable to benefit from these developments. We propose a complementary model …

Environmental enrichment for mice lags behind the standard enrichment offered to other
laboratory rodents due to concerns about environmental variability and, in specific contexts …