Targeting the mitotic machinery using anti-mitotic drugs for elimination of cancer cells is a
century-old concept, which continues to be routinely used as a first line of treatment in the …

Male fertility is closely related to the normal function of the hypothalamicpituitary-testicular
axis. The testis is an important male reproductive organ that secretes androgen and …

Abstract Mercuric chloride (HgCl 2), a heavy metal compound, causes neurotoxicity of
animals and humans. Selenium (Se) antagonizes heavy metal-induced organ damage with …

Objective To observe the brain protective effect of Leonuri Herba Total Alkali (LHA) on
cerebral ischemia reperfusion injury in rats, so as to provide basis for clinical research …

Centrosomal proteins are necessary components of the centrosome, a conserved eukaryotic
organelle essential to the reproductive process. However, few centrosomal proteins have …

Centrosomal protein dysfunction might cause ciliopathies. However, the role of centrosomal
proteins in male infertility remains poorly defined. Here, we identified a pathogenic splicing …

Triple‐negative breast cancer (TNBCs) is a very aggressive and lethal form of breast cancer
with no effective targeted therapy. Neoadjuvant chemotherapies and radiotherapy remains a …

Purpose: Lacking effective targeted therapies, triple-negative breast cancer (TNBCs) is
highly aggressive and metastatic disease, and remains clinically challenging breast cancer …

Multiple myeloma (MM), the second most common haematological malignancy, is a clonal
plasma B-cell neoplasm that forms within the bone marrow. Despite recent advancements in …

Cancer-testis antigens (CTA) are tumor antigens, present in the germ cells of testes, ovaries
and trophoblasts, which undergo deregulated expression in the tumor and malignant cells …