The spatial regulation of protein translation is an efficient way to create functional and
structural asymmetries in cells. Recent research has furthered our understanding of how …

It is becoming increasingly apparent that translational control plays an important role in the
regulation of gene expression in eukaryotic cells. Most of the known physiological effects on …

Biomolecular condensates organize biochemical processes at the subcellular level and can
provide spatiotemporal regulation within a cell. Among these, ribonucleoprotein (RNP) …

Germ-line transformation via transposable elements is a powerful tool to study gene function
in Drosophila melanogaster. However, some inherent characteristics of transposon …

lin-4 encodes a small RNA that is complementary to sequences in the 3′ untranslated
region (UTR) of lin-14 mRNA and that acts to developmentally repress the accumulation of …

Abstract Piwi-associated RNAs (piRNAs), a specific class of 24-to 30-nucleotide-long RNAs
produced by the Piwi-type of Argonaute proteins, have a specific germline function in …

Activation of the zygotic genome is a prerequisite for the transition from maternal to zygotic
control of development. The onset of zygotic transcription has been well studied in somatic …

Asymmetrically distributed cytoplasmic determinants collectively termed germ plasm have
been shown to play an essential role in the development of primordial germ cells (PGCs) …

The zinc-finger protein Nanos and the RNA-binding protein Pumilio act together to repress
the translation of maternal hunchback RNA in the posterior of the Drosophila embryo …

Background: Localization of nanos mRNA to the posterior pole of the Drosophila embryo
directs local synthesis of Nanos protein that is essential for patterning of the anterior …