The need for understanding essential recognition events in chemistry and biology has
directed considerable efforts toward the development of chemical probes. Fluorescent …

The mitochondrion is often referred as the cellular powerhouse because the organelle
oxidizes organic acids and NADH derived from nutriments, converting around 40% of the …

Intracellular thermometry at the microscopic level is currently a hot topic. Herein we describe
a small molecule fluorescent thermometer targeting mitochondria (Mito thermo yellow). Mito …

Protein kinases (PKs) play an important role in the development and progression of cancer
by regulating cell growth, survival, invasion, metastasis, and angiogenesis. Dasatinib (BMS …

A cell is the smallest functional unit of life. All forms of life rely on cellular processes to
maintain normal functions, and changes in cell function induced by metabolic disturbances …

Mitochondria generate most of the heat in endotherms. Given some impedance of heat
transfer across protein-rich bioenergetic membranes, mitochondria must operate at a higher …

Mitochondrial temperature is produced by various metabolic processes inside the
mitochondria, particularly oxidative phosphorylation. It was recently reported that …

Small fluorescent molecules have been an important tool for fluorescence-based imaging,
thanks to their technical simplicity, sensitivity and structural flexibility. However, probing …

The identification of each cell type is essential for understanding multicellular communities.
Antibodies set as biomarkers have been the main toolbox for cell-type recognition, and …

Fluorescent small molecules have become indispensable tools for biomedical research
along with the rapidly developing optical imaging technology. We report here a neural stem …