Combinatorial strategies in fluorescent probe development
The need for understanding essential recognition events in chemistry and biology has
directed considerable efforts toward the development of chemical probes. Fluorescent …
directed considerable efforts toward the development of chemical probes. Fluorescent …
[HTML][HTML] The conundrum of hot mitochondria
D Macherel, F Haraux, H Guillou… - Biochimica et Biophysica …, 2021 - Elsevier
The mitochondrion is often referred as the cellular powerhouse because the organelle
oxidizes organic acids and NADH derived from nutriments, converting around 40% of the …
oxidizes organic acids and NADH derived from nutriments, converting around 40% of the …
Mitochondria-targeted fluorescent thermometer monitors intracellular temperature gradient
J SunáYoo - Chemical communications, 2015 - pubs.rsc.org
Intracellular thermometry at the microscopic level is currently a hot topic. Herein we describe
a small molecule fluorescent thermometer targeting mitochondria (Mito thermo yellow). Mito …
a small molecule fluorescent thermometer targeting mitochondria (Mito thermo yellow). Mito …
Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes
H Shi, CJ Zhang, GYJ Chen… - Journal of the American …, 2012 - ACS Publications
Protein kinases (PKs) play an important role in the development and progression of cancer
by regulating cell growth, survival, invasion, metastasis, and angiogenesis. Dasatinib (BMS …
by regulating cell growth, survival, invasion, metastasis, and angiogenesis. Dasatinib (BMS …
Diversity oriented fluorescence library approach (DOFLA) for live cell imaging probe development
A cell is the smallest functional unit of life. All forms of life rely on cellular processes to
maintain normal functions, and changes in cell function induced by metabolic disturbances …
maintain normal functions, and changes in cell function induced by metabolic disturbances …
[HTML][HTML] Hot mitochondria?
N Lane - PLoS biology, 2018 - journals.plos.org
Mitochondria generate most of the heat in endotherms. Given some impedance of heat
transfer across protein-rich bioenergetic membranes, mitochondria must operate at a higher …
transfer across protein-rich bioenergetic membranes, mitochondria must operate at a higher …
[HTML][HTML] Regulation of mitochondrial temperature in health and disease
Mitochondrial temperature is produced by various metabolic processes inside the
mitochondria, particularly oxidative phosphorylation. It was recently reported that …
mitochondria, particularly oxidative phosphorylation. It was recently reported that …
Advances in the design of cell-permeable fluorescent probes for applications in live cell imaging
SH Alamudi, YT Chang - Chemical Communications, 2018 - pubs.rsc.org
Small fluorescent molecules have been an important tool for fluorescence-based imaging,
thanks to their technical simplicity, sensitivity and structural flexibility. However, probing …
thanks to their technical simplicity, sensitivity and structural flexibility. However, probing …
Lipid-oriented live-cell distinction of B and T lymphocytes
The identification of each cell type is essential for understanding multicellular communities.
Antibodies set as biomarkers have been the main toolbox for cell-type recognition, and …
Antibodies set as biomarkers have been the main toolbox for cell-type recognition, and …
Neural stem cell specific fluorescent chemical probe binding to FABP7
SW Yun, C Leong, D Zhai, YL Tan… - Proceedings of the …, 2012 - National Acad Sciences
Fluorescent small molecules have become indispensable tools for biomedical research
along with the rapidly developing optical imaging technology. We report here a neural stem …
along with the rapidly developing optical imaging technology. We report here a neural stem …