Major depressive disorder (MDD) is common and moderately heritable. Recurrence and
early age at onset characterize cases with the greatest familial risk. Major depressive …

Much work has been done to identify susceptibility genes in schizophrenia and bipolar
disorder. Several well established linkages have emerged in schizophrenia. Strongly …

Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has antidepressant-
like effects in animals and may be implicated in the etiology of mood-related phenotypes …

BACKGROUND: There is an increasing recognition that the pathophysiology of mental
disorders could be the result of deregulation of synaptic plasticity with alterations of …

It has been conventional for psychiatric research, including the search for predisposing
genes, to proceed under the assumption that schizophrenia and bipolar disorder are …

BACKGROUND: Previous genetic studies investigating a possible involvement of variations
at the brain derived neurotrophic factor (BDNF) gene locus in major depressive disorder …

The enormous public health importance of mood disorders, when considered alongside
their substantial heritabilities, has stimulated much work, predominantly in bipolar disorder …

Initial descriptions of bipolar disorder (BD) emphasized that patients returned to a baseline
condition after acute episodes. Such definitions were operational in teasing bipolar disorder …

The brain-derived neurotrophic factor (BDNF) gene is a candidate gene for influencing the
clinical response to treatment with antidepressants. The purpose of this study was to …

Brain-derived neurotrophic factor (BDNF), the most abundant neurotrophin in the brain,
serves an important role during brain development and in synaptic plasticity. Given its …