Lymph nodes (LNs), where immune responses are initiated, are organized into distinctive
compartments by fibroblastic reticular cells (FRCs). FRCs imprint immune responses by …

Stromal cells have for a long time been viewed as structural cells that support distinct
compartments within lymphoid tissues and little more. Instead, an active cross-talk between …

Ovarian fibrosis is a pathological condition associated with aging and is responsible for a
variety of ovarian dysfunctions. Given the known contributions of tissue fibrosis to …

B cells constitute a major component of infiltrating immune cells in colorectal cancer (CRC).
However, the characteristics of B cells and their clinical significance remain unclear. In this …

Objective To better understand the immune microenvironment of pancreatic ductal
adenocarcinomas (PDACs), here we explored the relevance of T and B cell …

Abstract Anti-synthetase syndrome (ASyS)-associated myositis is a major subgroup of the
idiopathic inflammatory myopathies (IIM) and is characterized by disease chronicity with …

Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by
abscesses, nodules, dissecting/draining tunnels, and extensive fibrosis. Here, we integrate …

Aims Recent studies have revealed that B cells and antibodies can influence inflammation
and remodelling following a myocardial infarction (MI) and culminating in heart failure—but …

Fibroblastic reticular cells (FRCs) are specialized fibroblasts of secondary lymphoid organs
that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to …

The opposing roles of innate and adaptive immune cells in suppressing or supporting
cancer initiation, progression, metastasis and response to therapy has been long debated …