[HTML][HTML] Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis
P Ge, Y Luo, CS Okoye, H Chen, J Liu, G Zhang… - Biomedicine & …, 2020 - Elsevier
Severe acute pancreatitis (SAP), a serious inflammatory disease of the pancreas, can easily
lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction …
lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction …
[HTML][HTML] Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases
X Verhelst, AM Dias, JF Colombel, S Vermeire… - Gastroenterology, 2020 - Elsevier
Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate
their structure and function. Glycans modify proteins required for regulation of immune cells …
their structure and function. Glycans modify proteins required for regulation of immune cells …
[HTML][HTML] On the role of the immunoproteasome in protein homeostasis
M Basler, M Groettrup - Cells, 2021 - mdpi.com
Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …
Disposing of misfolded ER proteins: a troubled substrate's way out of the ER
C Oikonomou, LM Hendershot - Molecular and cellular endocrinology, 2020 - Elsevier
Secreted, plasma membrane, and resident proteins of the secretory pathway are
synthesized in the endoplasmic reticulum (ER) where they undergo post-translational …
synthesized in the endoplasmic reticulum (ER) where they undergo post-translational …
Salidroside alleviated hypoxia-induced liver injury by inhibiting endoplasmic reticulum stress-mediated apoptosis via IRE1α/JNK pathway
Y Xiong, Y Wang, Y Xiong, W Gao, L Teng - Biochemical and Biophysical …, 2020 - Elsevier
Endoplasmic reticulum (ER) stress and subsequent apoptosis played vital role in liver injury
and dysfunction. The aim of this study was to investigate the protective effect and …
and dysfunction. The aim of this study was to investigate the protective effect and …
[HTML][HTML] Endoplasmic reticulum stress provocation by different nanoparticles: an innovative approach to manage the cancer and other common diseases
A proper execution of basic cellular functions requires well-controlled homeostasis including
correct protein folding. Endoplasmic reticulum (ER) implements such functions by protein …
correct protein folding. Endoplasmic reticulum (ER) implements such functions by protein …
[HTML][HTML] PARP1-catalyzed PARylation of YY1 mediates endoplasmic reticulum stress in granulosa cells to determine primordial follicle activation
W Chen, QE, B Sun, P Zhang, N Li, S Fei… - Cell Death & …, 2023 - nature.com
Although only a small number of primordial follicles are known to be selectively activated
during female reproductive cycles, the mechanisms that trigger this recruitment remain …
during female reproductive cycles, the mechanisms that trigger this recruitment remain …
[HTML][HTML] EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis
J Tan, R Cao, L Zhou, Z Zhou, H Chen, J Xu… - Cell death & …, 2020 - nature.com
Abstract Treatment of acute pancreatitis (AP) and chronic pancreatitis (CP) remains
problematic due to a lack of knowledge about disease-specific regulatory targets and …
problematic due to a lack of knowledge about disease-specific regulatory targets and …
[HTML][HTML] NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation
Pancreatic acinar cells rely on PTF1 and other transcription factors to deploy their
transcriptional program. We identify NFIC as a NR5A2 interactor and regulator of acinar …
transcriptional program. We identify NFIC as a NR5A2 interactor and regulator of acinar …
Silica nanoparticles induce caspase-dependent apoptosis through reactive oxygen species-activated endoplasmic reticulum stress pathway in neuronal cells
KI Lee, JW Lin, CC Su, KM Fang, CY Yang, CY Kuo… - Toxicology in Vitro, 2020 - Elsevier
Human exposure to silica nanoparticles (SiNPs) has been widely applied as vehicles for
drug delivery and cellular manipulations in nanoneuromedicine. SiNPs may cause adverse …
drug delivery and cellular manipulations in nanoneuromedicine. SiNPs may cause adverse …