Drug bioavailability is a crucial aspect of pharmacology, affecting the effectiveness of drug
therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in …

It is well‐accepted that off‐label drug dosing recommendations for pediatric patients should
be based on the best available evidence. However, the available traditional evidence is …

The fish plasma model (FPM) facilitated the environmental risk assessment of human drugs
by using existing data on human therapeutic plasma concentrations (HT PCs) and predicted …

The activity of cytochrome P450 enzymes is influenced by genetic and nongenetic factors;
hence, the metabolism of exogenous psychotropic medications and potentially some …

Pharmaceutical residues are increasingly becoming a significant source of environmental
water pollution and ecological risk. This study, leveraging official national pharmaceutical …

The concomitant administration of ritonavir and oxycodone may significantly increase the
plasma concentrations of oxycodone. This study was aimed to simulate DDI between …

In vitro biotransformation assays with primary trout hepatocytes (RT-HEP) or liver subcellular
fractions (RT-S9) have been proposed as valuable tools to help scientists and regulators …

In the past, rifampicin was well‐established as strong index CYP3A inducer in clinical drug–
drug interaction (DDI) studies. However, due to identified potentially genotoxic nitrosamine …

N‐Nitrosamine (NA) impurities are considered genotoxic and have gained attention due to
the recall of several marketed drug products associated with higher‐than‐permitted limits of …

Abstract Effects of non-antibiotic pharmaceuticals on antibiotic resistance genes (ARGs) in
soil ecosystem are still unclear. In this study, we explored the microbial community and …