GABAA receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …

Abstract Pyrazolo [1, 5-a] pyrimidine scaffold is one of the privileged hetrocycles in drug
discovery. Its application as a buliding block for developing drug-like candidates has …

Pyrazolo [1, 5-a] pyrimidines are the dominant motif of many drugs; for instance, zaleplon
and indiplon are sedative agents and ocinaplon was identified as an anxiolytic agent. The …

In this study, we aimed to establish two new series of pyrazolo [1, 5‐a] pyrimidines starting
from 1H‐pyrazole‐3, 5‐diamine. The first series was prepared by reacting 1H‐pyrazole‐3, 5 …

In the current study, a three-component protocol was adopted to efficiently synthesize
butane-linked bis (pyrazolo [1, 5-a] pyrimidines) 1 attached to arene units in 74–81% yields …

A series of new 5-alkyl and 5-arylisoxazolo [4, 5-d] pyrimidinones (5a–g, 6–8) were
prepared from 4-amino-3-oxo-isoxazolidine-5-carboxylic acid amide. Some of the aryl …

In our pursuit to identify selective ligands for Bz/GABAA receptor subtypes, a novel pyrazolo
[1, 5-a] pyrimidine derivative (4), the azaisostere of zolpidem, was synthesized and …

The γ-aminobutyric acid type A (GABAA) receptors are the major inhibitory neuronal
receptors in the mammalian brain. Their activation by GABA opens the intrinsic ion channel …

In the present study, a facile method was adopted to efficiently prepare new pyrazolo [1, 5-a]
pyrimidin-2-amines linked to arene units in good to excellent yields. A mixture of …

GABAA receptor modulators are structurally almost as diverse as their target protein. A
plethora of heterocyclic scaffolds has been described as modulating this extremely important …