Phosphorus-containing drugs belong to an important class of therapeutic agents and are
widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can …

Tumor angiogenesis is recognized as a major therapeutic target in the fight against cancer.
The key involvement of angiogenesis in tumor growth and metastasis has started to redefine …

Tissue-resident macrophages can self-maintain without contribution of adult hematopoiesis.
Herein we show that tissue-resident interstitial macrophages (Res-TAMs) in mouse lungs …

Abstract The 11 th St Gallen (Switzerland) expert consensus meeting on the primary
treatment of early breast cancer in March 2009 maintained an emphasis on targeting …

An enduring problem in cancer research is the failure to reproduce highly encouraging
preclinical therapeutic findings using transplanted or spontaneous primary tumours in mice …

It has been nearly 9years since the FDA (Food and Drug Administration) approved the first
anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other …

The ability of tumor cells to escape tumor immunosurveillance contributes to cancer
development. Factors produced in the tumor microenvironment create “tolerizing” conditions …

Simple Summary The present article reviews the state of the art of metronomic
chemotherapy use to treat the principal types of cancers, namely breast, non-small cell lung …

The immune system regulates angiogenesis in cancer with both pro-and antiangiogenic
activities. The induction of angiogenesis is mediated by tumor-associated macrophages and …

Metronomic chemotherapy describes the close, regular administration of chemotherapy
drugs at less-toxic doses over prolonged periods of time. In 2015, the results of randomized …