During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

The heme protein myeloperoxidase (MPO) is a major constituent of neutrophils. As a key
mediator of the innate immune system, neutrophils are rapidly recruited to inflammatory …

Atherosclerosis is the main pathophysiological process underlying coronary artery disease
(CAD). Acute complications of atherosclerosis, such as myocardial infarction, are caused by …

Myocardial infarction (MI) is one of the most common cardiac emergencies with high
morbidity and is a leading cause of death worldwide. Since MI could develop into a life …

Kinins are generated within inflammatory tissue microenvironments, where they exert
diverse functions, including cell proliferation, leukocyte activation, cell migration, endothelial …

Introduction: Kinins are peptide mediators exerting their pro-inflammatory actions by the
selective stimulation of two distinct G-protein coupled receptors, termed BKB1R and BKB2R …

Microglia are highly sensitive to even small changes in the brain environment, such as
invasion of non-hazardous toxicants or the presymptomatic state of diseases. However, the …

Intracellular myeloperoxidase (MPO) plays a specific role in the innate immune response;
however, upon release into the extracellular space in the setting of inflammation, drives …

Background Chronic Obstructive Pulmonary Disease (COPD) is currently the fifth leading
cause of death worldwide. Neutrophilic inflammation is prominent, worsened during infective …

Phospholipase D (PLD), which produces the lipid messenger phosphatidic acid (PA), has
been implicated in superoxide generation and degranulation in neutrophils. The basis for …