It is well known that oxidative stress and lipid peroxidation (LPO) play a role in physiology
and pathology. The most studied LPO product with pleiotropic capabilities is 4 …

Covalent crosslinks within or between proteins play a key role in determining the structure
and function of proteins. Some of these are formed intentionally by either enzymatic or …

The outrageous level of carbon dioxide (CO 2) accumulation in the atmosphere due to
persistent burning of fossil fuels is a serious problem to manhood, and there is upthrust …

Reactive oxygen species (ROS), and in particular H2O2, serve as essential second
messengers at low concentrations. However, excessive ROS accumulation leads to severe …

In laboratory experiments, many electrophilic cytotoxic agents induce cell death
accompanied by reactive oxygen species (ROS) production and/or by glutathione (GSH) …

The surge of scientific interest in the discovery of Nuclear Factor Erythroid 2 (NFE2)-Related
Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic …

Efficient functionalization of peptides and proteins has widespread applications in chemical
biology and drug discovery. However, the chemoselective and site-selective modification of …

Background Pancreatic cancer is one of the most common malignant tumors of the digestive
tract. Ponicidin, a tetracyclic diterpenoid active ingredient extracted from the traditional …

Oxidative stress and the accompanying chronic inflammation constitute an important
metabolic problem that may lead to pathology, especially when the body is exposed to …

Humans have widespread exposure to both oxidants, and soft electrophilic compounds such
as alpha, beta-unsaturated aldehydes and quinones. Electrophilic motifs are commonly …