Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …

Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …

Eukaryotic chromosomes contain compartments of various functions, which are marked by
and enriched with specific histone modifications. However, the molecular mechanisms by …

Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …

Progress in development of biophysical analytic approaches has recently crossed paths with
macromolecule condensates in cells. These cell condensates, typically termed liquid-like …

Heterochromatin plays important roles in transcriptional silencing and genome maintenance
by the formation of condensed chromatin structures, which determine the epigenetic status …

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a
diverse array of posttranslational modifications that largely impinge on histone amino …

Cellular senescence is an extremely stable form of cell cycle arrest that limits the
proliferation of damaged cells and may act as a natural barrier to cancer progression. In this …

Abstract Heterochromatin protein 1 (HP1) is localized at heterochromatin sites where it
mediates gene silencing,. The chromo domain of HP1 is necessary for both targeting and …

Distinct modifications of histone amino termini, such as acetylation, phosphorylation and
methylation, have been proposed to underlie a chromatin-based regulatory mechanism, that …