The molecular basis of heterochromatin assembly and epigenetic inheritance
SIS Grewal - Molecular cell, 2023 - cell.com
Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …
silencing of repetitive DNA elements. Histone modifications are essential for the …
Ten principles of heterochromatin formation and function
RC Allshire, HD Madhani - Nature reviews Molecular cell biology, 2018 - nature.com
Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …
particular genomic domains with specific functional properties. The capacity of …
Histone modifications regulate chromatin compartmentalization by contributing to a phase separation mechanism
Eukaryotic chromosomes contain compartments of various functions, which are marked by
and enriched with specific histone modifications. However, the molecular mechanisms by …
and enriched with specific histone modifications. However, the molecular mechanisms by …
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
Biological phase separation: cell biology meets biophysics
Progress in development of biophysical analytic approaches has recently crossed paths with
macromolecule condensates in cells. These cell condensates, typically termed liquid-like …
macromolecule condensates in cells. These cell condensates, typically termed liquid-like …
Structural basis of heterochromatin formation by human HP1
S Machida, Y Takizawa, M Ishimaru, Y Sugita, S Sekine… - Molecular cell, 2018 - cell.com
Heterochromatin plays important roles in transcriptional silencing and genome maintenance
by the formation of condensed chromatin structures, which determine the epigenetic status …
by the formation of condensed chromatin structures, which determine the epigenetic status …
Translating the histone code
T Jenuwein, CD Allis - Science, 2001 - science.org
Chromatin, the physiological template of all eukaryotic genetic information, is subject to a
diverse array of posttranslational modifications that largely impinge on histone amino …
diverse array of posttranslational modifications that largely impinge on histone amino …
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Cellular senescence is an extremely stable form of cell cycle arrest that limits the
proliferation of damaged cells and may act as a natural barrier to cancer progression. In this …
proliferation of damaged cells and may act as a natural barrier to cancer progression. In this …
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
Abstract Heterochromatin protein 1 (HP1) is localized at heterochromatin sites where it
mediates gene silencing,. The chromo domain of HP1 is necessary for both targeting and …
mediates gene silencing,. The chromo domain of HP1 is necessary for both targeting and …
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
M Lachner, D O'Carroll, S Rea, K Mechtler, T Jenuwein - Nature, 2001 - nature.com
Distinct modifications of histone amino termini, such as acetylation, phosphorylation and
methylation, have been proposed to underlie a chromatin-based regulatory mechanism, that …
methylation, have been proposed to underlie a chromatin-based regulatory mechanism, that …