Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress‐induced cardiac
channelopathy that has a high mortality in untreated patients. Our understanding has grown …

Heart contraction vitally depends on tightly controlled intracellular Ca regulation. Because
contraction is mainly driven by Ca released from the sarcoplasmic reticulum (SR), this …

Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited
cardiac arrhythmia characterized by adrenergically triggered arrhythmias, is inadequately …

Background: Genetic variants in calsequestrin-2 (CASQ2) cause an autosomal recessive
form of catecholaminergic polymorphic ventricular tachycardia (CPVT), although isolated …

In this final of a 5-part Focus Seminar series on precision medicine, we focus on
catecholaminergic polymorphic ventricular tachycardia (CPVT). This focus on CPVT allows …

BACKGROUND: Pathogenic variants in PKP2 (plakophilin-2) cause arrhythmogenic right
ventricular cardiomyopathy, a disease characterized by life-threatening arrhythmias and …

Here we report the structure of the widely utilized calmodulin (CaM)-dependent protein
kinase II (CaMKII) inhibitor KN93 bound to the Ca 2+-sensing protein CaM. KN93 is widely …

Rationale: Ca2+ alternans plays an essential role in cardiac alternans that can lead to
ventricular fibrillation, but the mechanism underlying Ca2+ alternans remains undefined …

A rapid growth in the incidence of diabetes and obesity has transpired to a major heath
issue and economic burden in the postindustrial world, with more than 29 million patients …