This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

Folates have a pterine core structure and high metabolic activity due to their ability to accept
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …

Drug development suffers from a lack of predictive and human-relevant in vitro models.
Organ-on-chip (OOC) technology provides advanced culture capabilities to generate …

At a population level, there is growing evidence of the beneficial effects of dietary flavonoids
on health. However, there is extensive heterogeneity in the response to increased intake …

Animals are biological transformers of dietary matter and energy to produce high-quality
foods and wools for human consumption and use. Mammals, birds, fish, and shrimp require …

Potential drug–drug interactions mediated by the ATP-binding cassette (ABC) transporter
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …

Neurodegenerative disorders are chronic and life-threatening conditions negatively affecting
the quality of patients' lives. They often have a genetic background, but oxidative stress and …

Abstract Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by
mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the …

Results We identified 74 studies, including 21 epidemiologic, 13 pharmacokinetic, and 40
toxicological studies. Three population-based epidemiologic studies demonstrated …

The proximal tubule of the kidney plays a crucial role in the renal handling of drugs (eg,
diuretics), uremic toxins (eg, indoxyl sulfate), environmental toxins (eg, mercury, aristolochic …