Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit
signals from their receptors to regulate gene expression and prevent apoptosis. Some …

An abundance of scientific literature exists demonstrating that oxidative stress influences the
MAPK signaling pathways. This review summarizes these findings for the ERK, JNK, p38 …

▪ Abstract Neurotrophins are a family of growth factors critical for the development and
functioning of the nervous system. Although originally identified as neuronal survival factors …

Brain-derived neurotrophic factor (BDNF) is a potent modulator of synaptic transmission and
plasticity in the CNS, acting both pre-and postsynaptically. We demonstrated recently that …

Extracellular signal-regulated kinase 5 (ERK5), also termed big mitogen-activated protein
kinase-1 (BMK1), is the most recently identified member of the mitogen-activated protein …

Abstract Information storage in the brain is a temporally graded process involving different
memory types or phases. It has been assumed for over a century that one or more short …

Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2), which are members of the
mitogen-activated protein kinase superfamily, have been well characterized and are known …

Growth factors synthesized and released by target tissues promote survival and
differentiation of innervating neurons. This retrograde signal begins when growth factors …