In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …

The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth,
survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to …

Intratumoral immunotherapy is an emerging modality for the treatment of solid tumors. Toll-
like receptor (TLR) agonists have shown promise for eliciting immune responses, but …

Ferroptosis, a new form of regulated cell death triggered by the iron-dependent peroxidation
of phospholipids, is associated with cellular metabolism, redox homeostasis, and various …

Platelets play significant and varied roles in cancer progression, as detailed throughout this
review series, via direct interactions with cancer cells and by long-range indirect interactions …

Cardiovascular disease and cancer are the 2 leading causes of death worldwide. Emerging
evidence suggests common mechanisms between cancer and cardiovascular disease …

Surgical removal of malignant tumors is a mainstay in controlling most solid cancers.
However, surgical insult also increases the risk of tumor recurrence and metastasis. Tissue …

Platelets are small anucleate cellular fragments that are released by megakaryocytes and
safeguard vascular integrity through a process termed 'haemostasis'. However, platelets …

Increasing evidence suggests that platelets play a predominant role in colon and breast
cancer metastasis, but the underlying molecular mechanisms remain elusive. Glycoprotein …

Platelets have long been known to play important roles beyond hemostasis and thrombosis.
Now recognized as a bona fide mediator of malignant disease, platelets influence various …