[HTML][HTML] The anti-PLA2R antibody in membranous nephropathy: what we know and what remains a decade after its discovery
AE van de Logt, M Fresquet, JF Wetzels, P Brenchley - Kidney international, 2019 - Elsevier
The discovery in 2009 of the M-type phospholipase A2 receptor (PLA2R) as the primary
target in membranous nephropathy (MN) greatly advanced basic and clinical research …
target in membranous nephropathy (MN) greatly advanced basic and clinical research …
[HTML][HTML] Update on IgG4-mediated autoimmune diseases: new insights and new family members
I Koneczny - Autoimmunity Reviews, 2020 - Elsevier
Antibodies of IgG4 subclass are exceptional players of the immune system, as they are
considered to be immunologically inert and functionally monovalent, and as such may be …
considered to be immunologically inert and functionally monovalent, and as such may be …
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …
Serine protease HTRA1 as a novel target antigen in primary membranous nephropathy
LF Al-Rabadi, T Caza, C Trivin-Avillach… - Journal of the …, 2021 - journals.lww.com
Background Identification of target antigens PLA2R, THSD7A, NELL1, or Semaphorin-3B
can explain the majority of cases of primary membranous nephropathy (MN). However …
can explain the majority of cases of primary membranous nephropathy (MN). However …
The annexin A2/S100A10 complex: the mutualistic symbiosis of two distinct proteins
A Bharadwaj, E Kempster, DM Waisman - Biomolecules, 2021 - mdpi.com
Mutualistic symbiosis refers to the symbiotic relationship between individuals of different
species in which both individuals benefit from the association. S100A10, a member of the …
species in which both individuals benefit from the association. S100A10, a member of the …
A point-of-care immunosensor based on a quartz crystal microbalance with graphene biointerface for antibody assay
We present a sensitive and low-cost immunoassay, based on a customized open-source
quartz crystal microbalance coupled with graphene biointerface sensors (G-QCM), to …
quartz crystal microbalance coupled with graphene biointerface sensors (G-QCM), to …
Common denominators in the immunobiology of IgG4 autoimmune diseases: what do glomerulonephritis, pemphigus vulgaris, myasthenia gravis, thrombotic …
IgG4 autoimmune diseases (IgG4-AID) are an emerging group of autoimmune diseases that
are caused by pathogenic autoantibodies of the IgG4 subclass. It has only recently been …
are caused by pathogenic autoantibodies of the IgG4 subclass. It has only recently been …
[HTML][HTML] Rapamycin attenuates PLA2R activation-mediated podocyte apoptosis via the PI3K/AKT/mTOR pathway
TTY Chiou, YY Chau, JB Chen, HH Hsu… - Biomedicine & …, 2021 - Elsevier
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults
without diabetes. Primary MN has been associated with circulating antibodies against native …
without diabetes. Primary MN has been associated with circulating antibodies against native …
Deficiency of mitochondrial glycerol 3-phosphate dehydrogenase exacerbates podocyte injury and the progression of diabetic kidney disease
H Qu, X Gong, X Liu, R Zhang, Y Wang, B Huang… - Diabetes, 2021 - Am Diabetes Assoc
Mitochondrial function is essential for bioenergetics, metabolism, and signaling and is
compromised in diseases such as proteinuric kidney diseases, contributing to the global …
compromised in diseases such as proteinuric kidney diseases, contributing to the global …