Chiral β-nitroalcohols find significant application in organic synthesis due to the versatile
reactivity of hydroxyl and nitro functionalities attached to one or two vicinal asymmetric …

Hydroxynitrile lyases (HNLs) primarily catalyze the stereoselective synthesis of
cyanohydrins, but some of them also carry out asymmetric nitroaldol synthesis (Henry …

Arabidopsis thaliana hydroxynitrile lyase (AtHNL) engineering has uncovered variants that
showed up to 12-fold improved catalytic efficiency than the wild-type towards asymmetric …

Diastereoselective Henry reaction (DHR) is an effective direct C–C bond ligation
transformation that enables the synthesis of β-nitroalcohols having two contiguous chiral …

The chiral vicinal C–O/C–N bifunctional groups generated from enzymatic hydrocyanation
represents a useful methodology. However, construction of the pharmacophore of β2 …

Kinetics of Henry reaction was performed to investigate the performance of
fluorapatite.(FAP) catalyst. It was found that the catalyst showed the highest conversion and …

Protein engineering to improve promiscuous catalytic activity is important for biocatalytic
application of enzymes in green synthesis. We uncovered the significance of binding site …

Biocatalytic asymmetrization of inexpensive and stable primary alcohols to prepare
enantioenriched β‐nitroalcohols is an important development in green chemistry for the …

Enantiopure β-nitroalcohols are versatile intermediates used in the synthesis of important
pharmaceuticals and chiral synthons. In this article, immobilized Arabidopsis thaliana HNL …

Granulicella tundricola hydroxynitrile lyase (Gt HNL) catalyses the synthesis of chiral (R)-
cyanohydrins and (R)-β-nitro alcohols. The triple variant Gt HNL-A40H/V42T/Q110H (Gt …