5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Serotonin (5-hydroxytryptamine; 5-HT) is a monoamine neurotransmitter whose effects are
mediated by at least 13 distinct G protein-coupled receptors (GPCRs) of the type A family …

Opiates are widely used analgesics in anesthesiology, but they have serious adverse effects
such as depression of breathing. This is caused by direct inhibition of rhythm-generating …

Rationale Current treatments for schizophrenia adequately treat the positive symptoms of
schizophrenia but only modestly improve cognitive deficits. This review provides evidence …

Serotonin 4 receptors (5-HT4Rs) were discovered 15 years ago. They are codedby a very
complex gene (700Kb, 38 exons) which generates eight carboxy-terminalvariants (a, b, c, d …

Serotonin is an ancient monoamine neurotransmitter, biochemically derived from
tryptophan. It is most abundant in the gastrointestinal tract, but is also present throughout the …

The constitutive activity of different serotonin receptors (5-HTRs) toward intracellular
signaling pathways has been proposed to have physiological and pathological importance …

Selective serotonin reuptake inhibitors are the mostly widely used treatment for major
depressive disorders and also are prescribed for several anxiety disorders. However, similar …

Abstract Serotonin (5-hydroxytryptamine or 5-HT) plays a critical physiological role in the
regulation of gastrointestinal (GI) function. 5-HT dysfunction may also be involved in the …

The 5-hydroxytryptamine type 4 receptor (5-HT4R) is involved in learning, feeding,
respiratory control and gastrointestinal transit. This receptor is one of the G-protein-coupled …