DNA methylation at the 5th position of cytosine (5mC) is one of the most studied epigenetic
mechanisms essential for the control of gene expression and for many other biological …

Epigenetic modifications are crucial regulators of gene expression that critically impact cell
lineage differentiation, survival, and proliferation, and dysregulations are commonly …

In brief Epigenetic programming is a crucial process during early embryo development that
can have a significant impact on the results of assisted reproductive technology (ART) and …

The quality of in vitro matured oocytes is inferior to that of in vivo matured oocytes, which
translates to low developmental capacity of embryos derived from in vitro matured oocytes …

Genetic modification of animals via selective breeding is the basis for modern agriculture.
The current breeding paradigm however has limitations, chief among them is the …

Atopic dermatitis (AD) is an allergic skin disease, triggered by excessive type 2 immune
reactions. Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine that …

Bisphenol A (BPA), an important environmental pollutant, is known to damage reproductive
development. However, the underlying epigenetic mechanism in Leydig cells during BPA …

Enzymes of the ten-eleven translocation family are considered to play an important role in
the regulation of DNA methylation patterns by converting 5-methylcytosine to 5 …

Early trophoblast differentiation is crucial for embryo implantation, placentation and fetal
development. Dynamic changes in DNA methylation occur during preimplantation …

Objective Discovering the mechanism of cell specification is important to manipulate cellular
lineages. To obtain lineage-specific cell lines, the target lineage needs to be promoted, and …