The dynamic properties of mitochondria—including their fusion, fission, and degradation—
are critical for their optimal function in energy generation. The interplay of fusion and fission …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Mitochondrial diseases are clinically heterogeneous disorders caused by a wide spectrum
of mutations in genes encoded by either the nuclear or the mitochondrial genome …

Mitochondria are subject to unique genetic control by both nuclear DNA and their own
genome, mitochondrial DNA (mtDNA), of which each mitochondrion contains multiple …

Understanding the mechanisms governing selective turnover of mutation-bearing mtDNA is
fundamental to design therapeutic strategies against mtDNA diseases. Here, we show that …

Mitochondrion harbors its own DNA (mtDNA), which encodes many critical proteins for the
assembly and activity of mitochondrial respiratory complexes. mtDNA is packed by many …

Impairment of PINK 1/parkin‐mediated mitophagy is currently proposed to be the molecular
basis of mitochondrial abnormality in Parkinson's disease (PD). We here demonstrate that …

Mitochondria contain their own genomes that, unlike nuclear genomes, are inherited only in
the maternal line. Owing to a high mutation rate and low levels of recombination of …

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

Mutations in mitochondrial DNA (mtDNA) play critical roles in many human diseases. In vivo
visualization of cells bearing mtDNA mutations is important for resolving the complexity of …