Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …

Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of
potentially damaging levels of reactive oxygen species (ROS), Ca2+, etc., which must be …

Obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), is linked with
increased reactive oxygen species/reactive nitrogen species (ROS/RNS) and oxidative …

Reductions in the blood supply produce considerable injury if the duration of ischemia is
prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue …

Objective The study was established to inquire into the protective effect of the HIF-1α
(Hypoxia-inducible factor-1α)/BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein) …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Empagliflozin (EMPA), a drug approved for type 2 diabetes management, reduced
cardiovascular death but is unknown if it reduces myocardial infarction. We sought to …

Cardiac hypertrophy is frequently associated with ventricular dysfunction and heart failure.
Paeoniflorin, has been widely used to treat cardiovascular dysfunction-related diseases …

Acute myocardial infarction (MI) is a major cause of death and disability worldwide. The
treatment of choice for reducing ischemic injury and limiting infarct size (IS) in patients with …