The extracellular matrix (ECM) has long been regarded as a packing material; supporting
cells within the tissue and providing tensile strength and protection from mechanical stress …

Heparan sulfate proteoglycans (HSPGs) are complex carbohydrate-modified proteins
ubiquitously expressed on cell surfaces, extracellular matrix and basement membrane of …

Glycosaminoglycans (GAGs) are abundant, ubiquitous carbohydrates in biology, yet their
structural complexity has limited an understanding of their biological roles and structure …

Nanoparticles (NPs) show great promise as tools for designing formulations capable of
meeting the challenge of targeted and non-targeted drug delivery to bone and cartilage …

Stem cells maintain a subtle balance between self-renewal and differentiation under the
regulatory network supported by both intracellular and extracellular components …

Osteoarthritis is a common, degenerative joint disease with significant socio-economic
impact worldwide. There are currently no disease-modifying drugs available to treat the …

The aim of this study was to highlight the roles of perlecan in the regulation of the
development of the rudiment developmental cartilages and growth plate cartilages, and also …

Serpins (ser ine p roteinase in hibitor s) are an ancient superfamily of structurally similar
proteins, the majority of which use an elegant suicide inhibition mechanism to target serine …

Summary HS3ST3B1-IT1 was identified as a downregulated long noncoding RNA in
osteoarthritic cartilage. However, its roles and mechanisms in the pathogenesis of …

Circular RNAs (circRNAs) titrate the function of microRNAs (miRNAs), regulate transcription,
and interfere with splicing. This study attempted to confirm the role of a novel circRNA …