[HTML][HTML] DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer
DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …
Genetic mechanisms of peripheral nerve disease
Peripheral neuropathies of genetic etiology are a very diverse group of disorders
manifesting either as non-syndromic inherited neuropathies without significant …
manifesting either as non-syndromic inherited neuropathies without significant …
The effects of chronic stress on brain myelination in humans and in various rodent models
E Antontseva, N Bondar, V Reshetnikov, T Merkulova - Neuroscience, 2020 - Elsevier
The myelination of axons, which is performed in brain tissues by specialized glial cells
(oligodendrocytes) is crucial for correct formation of the complicated neural circuitry …
(oligodendrocytes) is crucial for correct formation of the complicated neural circuitry …
[HTML][HTML] Identification of DNA methylation markers for early detection of CRC indicates a role for nervous system-related genes in CRC
G Rademakers, M Massen, A Koch, MX Draht… - Clinical …, 2021 - Springer
Purpose Colonoscopy and the fecal immunochemical test (FIT) are currently the most widely
used screening modalities for colorectal cancer (CRC), however, both with their own …
used screening modalities for colorectal cancer (CRC), however, both with their own …
[HTML][HTML] Investigating glioblastoma response to hypoxia
AL Chédeville, A Lourdusamy, AR Monteiro, R Hill… - Biomedicines, 2020 - mdpi.com
Glioblastoma (GB) is the most common and deadly type of primary malignant brain tumor
with an average patient survival of only 15–17 months. GBs typically have hypoxic regions …
with an average patient survival of only 15–17 months. GBs typically have hypoxic regions …
Lipid droplets are beneficial for rabies virus replication by facilitating viral budding
J Zhao, Z Zeng, Y Chen, W Liu, H Chen, ZF Fu… - Journal of …, 2022 - Am Soc Microbiol
Rabies is an old zoonotic disease caused by rabies virus (RABV), but the pathogenic
mechanism of RABV is still not completely understood. Lipid droplets (LDs) have been …
mechanism of RABV is still not completely understood. Lipid droplets (LDs) have been …
[HTML][HTML] VCE-005.1, an hypoxia mimetic betulinic acid derivative, induces angiogenesis and shows efficacy in a murine model of traumatic brain injury
ME Prados, C Navarrete, A García-Martín… - Biomedicine & …, 2023 - Elsevier
One of the main global causes of mortality and morbidity is traumatic brain injury (TBI).
Neuroinflammation and brain-blood barrier (BBB) disruption play a pivotal role in the …
Neuroinflammation and brain-blood barrier (BBB) disruption play a pivotal role in the …
Molecular docking of SARS-COV-2 Spike epitope sequences identifies heterodimeric peptide-protein complex formation with human Zo-1, TLR8 and brain specific …
S Dasgupta, M Bandyopadhyay - Medical hypotheses, 2021 - Elsevier
SARS-COV-2 infection causes severe respiratory tract illness leading to asphyxia and death.
The onset of infection is associated with loss of smell, blurred vision, headache with …
The onset of infection is associated with loss of smell, blurred vision, headache with …
N‐myc downstream regulated family member 1 (NDRG1) is enriched in myelinating oligodendrocytes and impacts myelin degradation in response to demyelination
D Marechal, DK Dansu, K Castro, J Patzig, L Magri… - Glia, 2022 - Wiley Online Library
The N‐myc downstream regulated gene family member 1 (NDRG1) is a gene whose
mutation results in peripheral neuropathy with central manifestations. While most of previous …
mutation results in peripheral neuropathy with central manifestations. While most of previous …
[HTML][HTML] Neurobiological opportunities in diabetic polyneuropathy
TM Poitras, E Munchrath, DW Zochodne - Neurotherapeutics, 2021 - Elsevier
This review highlights a selection of potential translational directions for the treatment of
diabetic polyneuropathy (DPN) currently irreversible and without approved interventions …
diabetic polyneuropathy (DPN) currently irreversible and without approved interventions …