[HTML][HTML] DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer

D Mueller, B Győrffy - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

Genetic mechanisms of peripheral nerve disease

M Stavrou, I Sargiannidou, T Christofi, KA Kleopa - neuroscience letters, 2021 - Elsevier
Peripheral neuropathies of genetic etiology are a very diverse group of disorders
manifesting either as non-syndromic inherited neuropathies without significant …

The effects of chronic stress on brain myelination in humans and in various rodent models

E Antontseva, N Bondar, V Reshetnikov, T Merkulova - Neuroscience, 2020 - Elsevier
The myelination of axons, which is performed in brain tissues by specialized glial cells
(oligodendrocytes) is crucial for correct formation of the complicated neural circuitry …

[HTML][HTML] Identification of DNA methylation markers for early detection of CRC indicates a role for nervous system-related genes in CRC

G Rademakers, M Massen, A Koch, MX Draht… - Clinical …, 2021 - Springer
Purpose Colonoscopy and the fecal immunochemical test (FIT) are currently the most widely
used screening modalities for colorectal cancer (CRC), however, both with their own …

[HTML][HTML] Investigating glioblastoma response to hypoxia

AL Chédeville, A Lourdusamy, AR Monteiro, R Hill… - Biomedicines, 2020 - mdpi.com
Glioblastoma (GB) is the most common and deadly type of primary malignant brain tumor
with an average patient survival of only 15–17 months. GBs typically have hypoxic regions …

Lipid droplets are beneficial for rabies virus replication by facilitating viral budding

J Zhao, Z Zeng, Y Chen, W Liu, H Chen, ZF Fu… - Journal of …, 2022 - Am Soc Microbiol
Rabies is an old zoonotic disease caused by rabies virus (RABV), but the pathogenic
mechanism of RABV is still not completely understood. Lipid droplets (LDs) have been …

[HTML][HTML] VCE-005.1, an hypoxia mimetic betulinic acid derivative, induces angiogenesis and shows efficacy in a murine model of traumatic brain injury

ME Prados, C Navarrete, A García-Martín… - Biomedicine & …, 2023 - Elsevier
One of the main global causes of mortality and morbidity is traumatic brain injury (TBI).
Neuroinflammation and brain-blood barrier (BBB) disruption play a pivotal role in the …

Molecular docking of SARS-COV-2 Spike epitope sequences identifies heterodimeric peptide-protein complex formation with human Zo-1, TLR8 and brain specific …

S Dasgupta, M Bandyopadhyay - Medical hypotheses, 2021 - Elsevier
SARS-COV-2 infection causes severe respiratory tract illness leading to asphyxia and death.
The onset of infection is associated with loss of smell, blurred vision, headache with …

N‐myc downstream regulated family member 1 (NDRG1) is enriched in myelinating oligodendrocytes and impacts myelin degradation in response to demyelination

D Marechal, DK Dansu, K Castro, J Patzig, L Magri… - Glia, 2022 - Wiley Online Library
The N‐myc downstream regulated gene family member 1 (NDRG1) is a gene whose
mutation results in peripheral neuropathy with central manifestations. While most of previous …

[HTML][HTML] Neurobiological opportunities in diabetic polyneuropathy

TM Poitras, E Munchrath, DW Zochodne - Neurotherapeutics, 2021 - Elsevier
This review highlights a selection of potential translational directions for the treatment of
diabetic polyneuropathy (DPN) currently irreversible and without approved interventions …