Abstract The Nobel Prize in Physiology or Medicine was recently awarded to Elizabeth
Blackburn, Carol Greider and Jack Szostak for their pioneering studies on chromosome …

Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …

Telomeres, the nucleoprotein structures at the ends of linear chromosomes, promote
genome stability by distinguishing chromosome termini from DNA double‐strand breaks …

The establishment of a specific nucleoprotein structure, the telomere, is required to ensure
the protection of chromosome ends from being recognized as DNA damage sites. Telomere …

The molecular era of telomere biology began with the discovery that telomeres usually
consist of G-rich simple repeats and end with 3′ single-stranded tails. Enormous progress …

Telomeres protect the ends of eukaryotic chromosomes from being recognized and
processed as double strand breaks. In most organisms, telomeric DNA is highly repetitive …

The evolutionarily conserved shelterin complex has been shown to play both positive and
negative roles in telomerase regulation in mammals and fission yeast. Although shelterin …

Putative TTAGGG repeat-binding factor (TRF) homologues in the genomes of Trypanosoma
brucei, Trypanosoma cruzi, and Leishmania major were identified. They have significant …

Collaborative studies open doors to breakthroughs otherwise unattainable by any one
laboratory alone. Here we describe the initial collaboration between the Griffith and de …

A major issue in telomere research is to understand how the integrity of chromosome ends is
controlled. The fact that different types of nucleoprotein complexes have been described at …