Nitric oxide (NO) is synthesized by a family of NO synthases (NOS), including neuronal,
inducible, and endothelial NOS (n/i/eNOS). NO-mediated effects can be beneficial or …

The global burden of kidney disease is increasing strikingly in parallel with increases in
obesity and diabetes. Indeed, chronic kidney disease (CKD) and end-stage renal disease …

Insulin resistance is a central component of the metabolic dysregulation observed in obesity,
which puts one at risk for the development of type 2 diabetes and complications related to …

Cardiovascular disorders are the most common cause of mortality in autosomal dominant
polycystic kidney disease (ADPKD). This review considers recent clinical and basic science …

Background The prominent features of autosomal dominant polycystic kidney disease
(ADPKD) are early development of hypertension, chronic kidney disease and cardiovascular …

Abstract TRPP2 (polycystin-2, PC2 or PKD2), encoded by the PKD2 gene, is a non-selective
cation channel with a large single channel conductance and high Ca 2+ permeability. In cell …

Objective: We analyzed the correlation between mutation in intron 4 and exon 7 of
endothelial nitric oxide synthase (eNOS) and avascular necrosis of femoral head (ANFH) …

Background: Hypertension is seen in 70% of autosomal dominant polycystic kidney disease
(ADPKD) patients by the age of 30 prior to decline in kidney function. However, cardiac …

Introduction: Endothelial nitric oxide synthase (eNOS) genes have been implicated in renal
hemodynamics as potent regulators of vascular tone and blood pressure. It has been linked …

Introduction: At present, treatment of autosomal dominant polycystic kidney disease
(ADPKD) is essentially supportive as there is still no specific therapy. However, recent …