Insulin is a peptide hormone known for chiefly regulating glucose level in blood among
several other metabolic processes. Insulin remains the most effective drug for treating …

Water is essential for the structure, dynamics, energetics, and thus the function of
biomolecules. It is a formidable challenge to elicit, in microscopic detail, the role of the …

The role of water in biological processes is studied in three reactions, namely, the Fe-CO
bond rupture in myoglobin, GB1 unfolding, and insulin dimer dissociation. We compute both …

Liquid–liquid phase separation (LLPS) plays a key role in the compartmentalization of cells
via the formation of biomolecular condensates. Here, we combined atomistic molecular …

Developing time‐sustained drug delivery systems is a main goal in innovative medicines.
Inspired by the architecture of secretory granules from the mammalian endocrine system it …

A theory of barrier crossing rate on a multidimensional reaction energy surface is presented.
The theory is a generalization of the earlier theoretical schemes to higher dimensions, with …

Diffusion in a multidimensional energy surface with minima and barriers is a problem of
importance in statistical mechanics and it also has wide applications, such as protein …

The task of a first principles theoretical calculation of the rate of gas–liquid nucleation has
remained largely incomplete despite the existence of reliable results from unbiased …

Abstract SEM1 (68–107) is a peptide corresponding to the region of semenogelin 1 protein
from 68 to 107 amino acid position. SEM1 (68–107) is an abundant component of semen …

The insulin hormone is stored in the hexameric form and dissociates to the dimeric form and
finally to the active monomeric form. When insulin secretion is impaired, thereby affecting …